:root {
            --color-accept: #22c55e;
            --color-remove: #ef4444;
            --color-modify: #f97316;
            --color-keep-non-core: #3b82f6;
            --color-undecided: #6b7280;
            --color-new: #8b5cf6;
            --color-mark-over: #eab308;
            --bg-light: #f9fafb;
            --border-color: #e5e7eb;
            --text-muted: #6b7280;
            --text-primary: #111827;
        }

        * {
            margin: 0;
            padding: 0;
            box-sizing: border-box;
        }

        body {
            font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif;
            line-height: 1.6;
            color: var(--text-primary);
            background-color: #ffffff;
            padding: 2rem;
            max-width: 1400px;
            margin: 0 auto;
        }

        .header {
            border-bottom: 2px solid var(--border-color);
            padding-bottom: 1.5rem;
            margin-bottom: 2rem;
        }

        .section-nav {
            display: flex;
            flex-wrap: wrap;
            gap: 0.625rem;
            margin-bottom: 2rem;
        }

        .section-nav a {
            display: inline-flex;
            align-items: center;
            gap: 0.5rem;
            padding: 0.625rem 0.875rem;
            border: 1px solid var(--border-color);
            border-radius: 0.5rem;
            background: var(--bg-light);
            color: #374151;
            text-decoration: none;
            font-size: 0.875rem;
            font-weight: 500;
        }

        .section-nav a:hover {
            background: #eff6ff;
            border-color: #93c5fd;
            color: #1e40af;
        }

        .section-nav a:focus-visible {
            outline: 3px solid #2563eb;
            outline-offset: 3px;
        }

        .section-nav .nav-count {
            font-weight: 700;
            font-variant-numeric: tabular-nums;
        }

        .section-nav .nav-external {
            border-color: #c4b5fd;
            background: #faf5ff;
            color: #5b21b6;
        }

        .section[id] {
            scroll-margin-top: 1rem;
        }

        h1 {
            font-size: 2.5rem;
            font-weight: 700;
            margin-bottom: 0.5rem;
            color: #1f2937;
        }

        .gene-info {
            display: flex;
            gap: 2rem;
            flex-wrap: wrap;
            margin-top: 1rem;
        }

        .info-item {
            display: flex;
            gap: 0.5rem;
        }

        .info-label {
            font-weight: 600;
            color: var(--text-muted);
        }

        .aliases {
            display: flex;
            gap: 0.5rem;
            flex-wrap: wrap;
        }

        .badge {
            padding: 0.25rem 0.75rem;
            border-radius: 9999px;
            font-size: 0.875rem;
            font-weight: 500;
            background-color: var(--bg-light);
            border: 1px solid var(--border-color);
        }

        .status-badge {
            padding: 0.375rem 0.875rem;
            border-radius: 0.375rem;
            font-size: 0.875rem;
            font-weight: 600;
            text-transform: uppercase;
            letter-spacing: 0.025em;
        }

        .status-initialized {
            background-color: #fef3c7;
            color: #92400e;
            border: 1px solid #fde68a;
        }

        .status-in-progress {
            background-color: #dbeafe;
            color: #1e40af;
            border: 1px solid #bfdbfe;
        }

        .status-draft {
            background-color: #fce7f3;
            color: #831843;
            border: 1px solid #fbcfe8;
        }

        .status-complete {
            background-color: #d1fae5;
            color: #065f46;
            border: 1px solid #a7f3d0;
        }

        .description-card {
            background-color: var(--bg-light);
            border: 1px solid var(--border-color);
            border-radius: 0.5rem;
            padding: 1.5rem;
            margin-bottom: 2rem;
        }

        .description-card h2 {
            font-size: 1.25rem;
            margin-bottom: 1rem;
            color: #374151;
        }

        .section {
            margin-bottom: 2.5rem;
        }

        .section-title {
            font-size: 1.5rem;
            font-weight: 600;
            margin-bottom: 1.5rem;
            color: #1f2937;
            border-bottom: 1px solid var(--border-color);
            padding-bottom: 0.5rem;
        }

        .annotations-table {
            width: 100%;
            border-collapse: collapse;
            border: 1px solid var(--border-color);
            border-radius: 0.5rem;
            overflow: hidden;
        }

        .annotations-table thead {
            background-color: var(--bg-light);
        }

        .annotations-table th {
            text-align: left;
            padding: 1rem;
            font-weight: 600;
            border-bottom: 2px solid var(--border-color);
            font-size: 0.875rem;
            text-transform: uppercase;
            letter-spacing: 0.05em;
            color: var(--text-muted);
        }

        .annotations-table td {
            padding: 1rem;
            border-bottom: 1px solid var(--border-color);
        }

        .annotations-table tbody tr:hover {
            background-color: #f9fafb;
        }

        .action-badge {
            display: inline-block;
            padding: 0.375rem 0.75rem;
            border-radius: 0.375rem;
            font-size: 0.875rem;
            font-weight: 600;
            text-transform: uppercase;
            letter-spacing: 0.025em;
        }

        .action-accept {
            background-color: var(--color-accept);
            color: white;
        }

        .action-remove {
            background-color: var(--color-remove);
            color: white;
        }

        .action-modify {
            background-color: var(--color-modify);
            color: white;
        }

        .action-keep_as_non_core {
            background-color: var(--color-keep-non-core);
            color: white;
        }

        .action-undecided {
            background-color: var(--color-undecided);
            color: white;
        }

        .action-new {
            background-color: var(--color-new);
            color: white;
        }

        .action-mark_as_over_annotated {
            background-color: var(--color-mark-over);
            color: white;
        }

        .term-info {
            display: flex;
            flex-direction: column;
            gap: 0.25rem;
        }

        .term-id {
            font-family: monospace;
            font-size: 0.875rem;
            color: var(--text-muted);
        }

        .term-label {
            font-weight: 500;
        }

        .evidence-code {
            font-family: monospace;
            background-color: var(--bg-light);
            padding: 0.125rem 0.375rem;
            border-radius: 0.25rem;
            font-size: 0.875rem;
        }

        .not-badge {
            display: inline-block;
            background-color: #fef2f2;
            color: #991b1b;
            border: 1px solid #fecaca;
            padding: 0.125rem 0.375rem;
            border-radius: 0.25rem;
            font-size: 0.75rem;
            font-weight: 600;
            margin-left: 0.25rem;
        }

        .isoform-badge {
            display: inline-block;
            background-color: #eff6ff;
            color: #1e40af;
            border: 1px solid #bfdbfe;
            padding: 0.125rem 0.375rem;
            border-radius: 0.25rem;
            font-size: 0.75rem;
            margin-top: 0.25rem;
        }

        .core-function-card {
            background-color: white;
            border: 1px solid var(--border-color);
            border-radius: 0.5rem;
            padding: 1.5rem;
            margin-bottom: 1rem;
        }

        .core-function-card h3 {
            font-size: 1.125rem;
            margin-bottom: 1rem;
            color: #1f2937;
        }

        .core-function-statement {
            margin-bottom: 1rem;
            padding: 0.75rem;
            background-color: var(--bg-light);
            border-left: 4px solid var(--color-accept);
            border-radius: 0.25rem;
        }

        .function-annotations {
            display: flex;
            flex-wrap: wrap;
            gap: 0.5rem;
            margin-top: 1rem;
        }

        .reference-item {
            border: 1px solid var(--border-color);
            border-radius: 0.5rem;
            padding: 1rem;
            margin-bottom: 1rem;
        }

        .reference-header {
            display: flex;
            justify-content: space-between;
            align-items: start;
            margin-bottom: 0.75rem;
        }

        .reference-id {
            font-family: monospace;
            font-weight: 600;
            color: #2563eb;
        }

        .supported-by {
            margin-top: 0.5rem;
            padding: 0.5rem;
            background-color: #f3f4f6;
            border-left: 3px solid #3b82f6;
            border-radius: 0.25rem;
            font-size: 0.875rem;
        }

        .supported-by-title {
            font-weight: 600;
            color: #4b5563;
            margin-bottom: 0.25rem;
        }

        .support-item {
            margin-bottom: 0.5rem;
        }

        .support-ref {
            font-weight: 500;
            color: #2563eb;
        }

        .support-text {
            color: #6b7280;
            font-style: italic;
            margin-left: 1rem;
        }

        .propagation-review {
            margin-top: 0.5rem;
            padding: 0.5rem;
            background-color: #f8fafc;
            border-left: 3px solid #64748b;
            border-radius: 0.25rem;
            font-size: 0.875rem;
        }

        .propagation-title {
            font-weight: 600;
            color: #334155;
            margin-bottom: 0.25rem;
        }

        .propagation-row {
            margin-top: 0.25rem;
        }

        .propagation-source {
            margin-top: 0.5rem;
            padding-top: 0.5rem;
            border-top: 1px solid #e5e7eb;
        }

        .propagation-source-id {
            font-family: monospace;
            font-weight: 600;
            color: #1d4ed8;
        }

        .propagation-comment {
            color: #4b5563;
            margin-left: 1rem;
        }

        a.term-link {
            color: #2563eb;
            text-decoration: none;
        }

        a.term-link:hover {
            text-decoration: underline;
        }

        .core-function-terms {
            margin-top: 1rem;
        }

        .function-term-group {
            margin-bottom: 1rem;
        }

        .function-term-label {
            font-weight: 600;
            color: #4b5563;
            margin-bottom: 0.25rem;
        }

        .reference-title {
            font-weight: 500;
            margin-bottom: 0.5rem;
        }

        .findings-list {
            margin-top: 1rem;
            padding-left: 1.5rem;
        }

        .finding-item {
            margin-bottom: 0.75rem;
        }

        .finding-statement {
            font-weight: 500;
            margin-bottom: 0.25rem;
        }

        .finding-text {
            color: var(--text-muted);
            font-size: 0.95rem;
            font-style: italic;
        }

        .proposed-term {
            border: 1px solid var(--border-color);
            border-radius: 0.5rem;
            padding: 1rem;
            margin-bottom: 1rem;
            background-color: #fef3c7;
        }

        .question-card {
            border: 1px solid var(--border-color);
            border-radius: 0.5rem;
            padding: 1rem;
            margin-bottom: 1rem;
            background-color: #dbeafe;
        }

        .experiment-card {
            border: 1px solid var(--border-color);
            border-radius: 0.5rem;
            padding: 1rem;
            margin-bottom: 1rem;
            background-color: #f3e8ff;
        }

        .external-predictions {
            border: 2px solid #a78bfa;
            border-left: 6px solid #7c3aed;
            border-radius: 0.5rem;
            padding: clamp(1rem, 2vw, 1.5rem);
            background: #faf5ff;
        }

        .prediction-notice {
            color: #4c1d95;
            margin-bottom: 1.25rem;
        }

        .prediction-review + .prediction-review {
            border-top: 1px solid #c4b5fd;
            margin-top: 1.5rem;
            padding-top: 1.5rem;
        }

        .prediction-review h3, .prediction-review > p {
            margin-bottom: 0.75rem;
        }

        .prediction-card {
            border: 1px solid var(--border-color);
            border-radius: 0.5rem;
            padding: 1rem;
            margin-bottom: 1rem;
            background-color: white;
        }

        .prediction-card .prediction-header {
            display: flex;
            flex-wrap: wrap;
            gap: 0.75rem;
            justify-content: space-between;
            align-items: center;
            margin-bottom: 0.75rem;
        }

        .prediction-source {
            font-size: 0.85rem;
            color: var(--text-muted);
            overflow-wrap: anywhere;
        }

        .assessment-badge {
            padding: 0.25rem 0.75rem;
            border-radius: 9999px;
            font-size: 0.8rem;
            font-weight: 600;
            text-transform: uppercase;
        }

        .assessment-cor { background-color: #dcfce7; color: #166534; }
        .assessment-cnn { background-color: #dbeafe; color: #1e40af; }
        .assessment-lsp { background-color: #fef9c3; color: #854d0e; }
        .assessment-unc { background-color: #f3f4f6; color: #374151; }
        .assessment-pli { background-color: #fee2e2; color: #991b1b; }
        .assessment-npi { background-color: #fecaca; color: #7f1d1d; }
        .assessment-rep { background-color: #fde68a; color: #92400e; }

        .confidence-score {
            font-size: 0.85rem;
            color: var(--text-muted);
            margin-left: 0.5rem;
        }

        .error-type-badge {
            font-size: 0.75rem;
            padding: 0.125rem 0.5rem;
            border-radius: 0.25rem;
            background-color: #fef2f2;
            color: #991b1b;
            border: 1px solid #fecaca;
        }

        .isoforms-grid {
            display: grid;
            grid-template-columns: repeat(auto-fill, minmax(400px, 1fr));
            gap: 1rem;
        }

        .isoform-card {
            border: 1px solid var(--border-color);
            border-radius: 0.5rem;
            padding: 1rem;
            background-color: white;
            transition: box-shadow 0.2s;
        }

        .isoform-card:hover {
            box-shadow: 0 2px 8px rgba(0, 0, 0, 0.1);
        }

        .functional-isoform-type {
            display: inline-block;
            padding: 0.2rem 0.5rem;
            border-radius: 0.25rem;
            font-size: 0.7rem;
            font-weight: 600;
            text-transform: uppercase;
            letter-spacing: 0.03em;
        }

        .type-SPLICE_VARIANT, .type-SPLICE_CLASS {
            background-color: #dbeafe;
            color: #1e40af;
            border: 1px solid #93c5fd;
        }

        .type-CLEAVAGE_PRODUCT {
            background-color: #fef3c7;
            color: #92400e;
            border: 1px solid #fcd34d;
        }

        .type-MODIFICATION_STATE {
            background-color: #f3e8ff;
            color: #6b21a8;
            border: 1px solid #c4b5fd;
        }

        .type-CONFORMATIONAL_STATE {
            background-color: #dcfce7;
            color: #166534;
            border: 1px solid #86efac;
        }

        .functional-isoform-mappings {
            margin-top: 0.5rem;
            padding: 0.5rem;
            background-color: var(--bg-light);
            border-radius: 0.25rem;
            font-size: 0.85rem;
        }

        .functional-isoform-mappings .mapping-type {
            font-weight: 600;
            color: var(--text-muted);
            font-size: 0.75rem;
        }

        .functional-isoform-go {
            margin-top: 0.5rem;
            display: flex;
            flex-wrap: wrap;
            gap: 0.25rem;
        }

        .go-chip {
            display: inline-block;
            padding: 0.15rem 0.4rem;
            background-color: #ecfdf5;
            color: #047857;
            border: 1px solid #a7f3d0;
            border-radius: 0.25rem;
            font-size: 0.75rem;
            font-family: monospace;
        }

        .isoform-header {
            display: flex;
            justify-content: space-between;
            align-items: center;
            margin-bottom: 0.75rem;
            padding-bottom: 0.5rem;
            border-bottom: 1px solid var(--border-color);
        }

        .isoform-name {
            font-weight: 600;
            font-size: 1.1rem;
            color: #1f2937;
        }

        .isoform-id {
            font-family: monospace;
            font-size: 0.875rem;
            color: var(--text-muted);
        }

        .isoform-sequence-note {
            font-size: 0.875rem;
            color: var(--text-muted);
            margin-bottom: 0.5rem;
            padding: 0.5rem;
            background-color: var(--bg-light);
            border-radius: 0.25rem;
        }

        .isoform-description {
            font-size: 0.95rem;
            line-height: 1.5;
        }

        .collapsible {
            cursor: pointer;
            user-select: none;
        }

        .collapsible:after {
            content: ' ▼';
            font-size: 0.75rem;
        }

        .collapsible.collapsed:after {
            content: ' ►';
        }

        .collapse-content {
            transition: max-height 0.3s ease;
            overflow: hidden;
        }

        .collapsed + .collapse-content {
            max-height: 0;
        }

        .no-data {
            color: var(--text-muted);
            font-style: italic;
            padding: 1rem;
            text-align: center;
            background-color: var(--bg-light);
            border-radius: 0.5rem;
        }

        /* Styling for markdown section summaries with voting */
        .markdown-section summary {
            padding: 0.75rem;
            background: var(--bg-light);
            border-radius: 0.5rem;
            margin-bottom: 0.5rem;
        }

        .markdown-section summary:hover {
            background: #e5e7eb;
        }

        .markdown-section summary .vote-buttons {
            margin-left: auto;
        }

        .deep-research-section {
            margin-bottom: 1rem;
            border: 1px solid #c7d2fe;
            border-radius: 8px;
            padding: 1rem;
            background-color: #f8faff;
        }

        .deep-research-section summary {
            cursor: pointer;
            user-select: none;
        }

        .deep-research-section summary h3 {
            margin: 0;
            color: #3730a3;
            font-size: 1.1rem;
        }

        .report-meta {
            display: flex;
            flex-wrap: wrap;
            gap: 0.5rem;
            margin: 0.75rem 0 1rem;
            align-items: center;
        }

        .report-badge {
            display: inline-flex;
            align-items: center;
            border: 1px solid #c7d2fe;
            border-radius: 999px;
            background: #eef2ff;
            color: #4338ca;
            font-size: 0.78rem;
            font-weight: 600;
            padding: 0.2rem 0.6rem;
        }

        .report-meta-text {
            color: var(--text-muted);
            font-size: 0.85rem;
        }

        .artifact-list {
            display: grid;
            gap: 0.75rem;
            margin: 0.75rem 0 1rem;
        }

        .artifact-link {
            color: var(--text-muted);
            font-size: 0.85rem;
            margin-top: 0.5rem;
            word-break: break-word;
        }

        @media print {
            body {
                padding: 1rem;
            }

            .collapsible:after {
                display: none;
            }

            .collapsed + .collapse-content {
                max-height: none !important;
            }
        }

        @media (max-width: 768px) {
            body {
                padding: 1rem;
            }

            h1 {
                font-size: 2rem;
            }

            .annotations-table {
                font-size: 0.875rem;
            }

            .annotations-table th,
            .annotations-table td {
                padding: 0.5rem;
            }
        }