Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry.
Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.
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In human platelets the type III IP3R is the plasma-membrane subtype and is the only IP3R significantly labelled by surface biotinylation of intact cells; type I IP3R is intracellular.
"In studies examining the labeling of surface proteins with biotin in intact platelets only the type III (1,4,5)IP(3)R was significantly labeled"
Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells.
Human Golgi antiapoptotic protein modulates intracellular calcium fluxes.
Defining the membrane proteome of NK cells.
Agonist-activated Ca2+ influx occurs at stable plasma membrane and endoplasmic reticulum junctions.
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A fraction of type III IP3R localises to ER-plasma-membrane peripheral junctions, the anatomical site of agonist-activated Ca2+ entry, shown by TIRF microscopy in HEK293 cells.
"These results indicate that a small percentage of junctate and Ins P 3 R3 colocalize in a domain closely adjacent to the PM"
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.
BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation.
Structural basis for the regulation of inositol trisphosphate receptors by Ca(2+) and IP(3).
STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca(2+) fluxes and apoptotic responses.
Dominant mutations in ITPR3 cause Charcot-Marie-Tooth disease.
Structural titration reveals Ca(2+)-dependent conformational landscape of the IP(3) receptor.
A pleiotropic recurrent dominant ITPR3 variant causes a complex multisystemic disease.
Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency.
Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium.
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol
Binding of IP3 to IP3 receptor
ER calcium channels open in response to activated PKA
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it
Sensory perception of sweet, bitter, and umami (glutamate) taste
I(1,4,5)P3 binds ITPR3 tetramer
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol
UniProtKB record for human ITPR3