Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core.

Human liver glycogen phosphorylase inhibitors bind at a new allosteric site.

Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.

High frequency of missense mutations in glycogen storage disease type VI.

Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

A proteome-scale map of the human interactome network.

Widespread macromolecular interaction perturbations in human genetic disorders.

A reference map of the human binary protein interactome.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Mutations in the liver glycogen phosphorylase gene (PYGL) underlying glycogenosis type VI.

poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]

Exocytosis of secretory granule lumen proteins

Exocytosis of ficolin-rich granule lumen proteins

glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP

glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]