Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Electronic Gene Ontology annotations created by ARBA machine learning models
Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors.
NMDA spikes in basal dendrites of cortical pyramidal neurons.
Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain.
NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit.
Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors.
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems.
Analysis of NR3A receptor subunits in human native NMDA receptors.
Enhanced ethanol inhibition of recombinant N-methyl-D-aspartate receptors by magnesium: role of NR3A subunits.
Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability.
A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes.
GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy.
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy.
Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy.
GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Structural basis of ketamine action on human NMDA receptors.
Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor.
Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel.
Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.
Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
EPHB phosphorylates TIAM1
p-TIAM1 exchanges GTP for GDP on RAC1, activating it
Ca2+ influx into the post-synaptic cell
RAS GEFs promote RAS nucleotide exchange
PSD-95 binds NMDA receptor
SALM2 associate with AMPA and NMDA receptors
SALM1 binds NMDA receptor
Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)
Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A)
GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane
Formation of tri-heterotetramers of GRIN1, Grin2a and Grin2c
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
NMDA receptor activation in differentiating cerebellar cell cultures regulates the expression of a new POU gene, Cns-1.
Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits.
Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability.
Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors.
Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction.
Direct interaction of myosin regulatory light chain with the NMDA receptor.
Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines.
Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine.
Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule.
Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.
Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses.
Crystal structure of a heterotetrameric NMDA receptor ion channel.
UniProtKB/Swiss-Prot entry Q05586 (NMDZ1_HUMAN)
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core.
OpenScientist deep research report for human GRIN1
The N-terminal domain of the GluN3A subunit determines the efficacy of glycine-activated NMDA receptors.
An ER retention signal explains differences in surface expression of NMDA and AMPA receptor subunits.
Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A.
Revisiting the postulated "unitary glutamate receptor": electrophysiological and pharmacological analysis in two heterologous expression systems fails to detect evidence for its existence.
Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function.
Unmasking GluN1/GluN3A excitatory glycine NMDA receptors.
OpenScientist hypothesis test: does GluN1 glycine-site occupancy inhibit GluN1/GluN3 current
OpenScientist hypothesis test: do GluN1-alone oocyte currents need an endogenous Xenopus GluN2 partner