Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

PMID:12176330

Inducible antibacterial defense system in C. elegans.

lys-1 is among the most robustly infection-induced genes and its overexpression augments resistance to the Gram-negative bacterium Serratia marcescens; the protein localizes to apical intestinal vesicles.

PMID:16968778

A conserved role for a GATA transcription factor in regulating epithelial innate immune responses.

Genome-wide study establishing the intestinal ELT-2/GATA-regulated epithelial infection-response gene program of which lys-1 is a member (basis of the HEP innate-immune-response annotation).

PMID:21209831

RNAi screen of DAF-16/FOXO target genes in C. elegans links pathogenesis and dauer formation.

lys-1 RNAi significantly reduces survival on Staphylococcus aureus (TD50 4.7 vs 6.8 days, p<0.0001), showing lys-1 is required for normal resistance; lys-1 is a DAF-16/FOXO target with a synthetic dauer-formation phenotype.

PMID:21931778

Protist-type lysozymes of the nematode Caenorhabditis elegans contribute to resistance against pathogenic Bacillus thuringiensis.

Classifies lys-1 as a chromosome V protist-type lysozyme within the 15-gene C. elegans lysozyme family, shows lys-1 is transcriptionally upregulated by B. thuringiensis in all tested strains, and states explicitly that no C. elegans lysozyme has been characterized at the protein level (basis of the muramidase-activity knowledge gap).