Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link.
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Collagen IV protomers (two alpha1, one alpha2) form a network giving basement membranes scaffold and mechanical strength; NC1 trimers are covalently cross-linked.
"anchoring scaffold and mechanical strength"
The human plasma proteome: a nonredundant list developed by combination of four separate sources.
Novel mutations in three families confirm a major role of COL4A1 in hereditary porencephaly.
COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps.
Cerebrovascular disease related to COL4A1 mutations in HANAC syndrome.
Novel COL4A1 mutations associated with HANAC syndrome: a role for the triple helical CB3[IV] domain.
Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.
Novel COL4A1 mutations cause cerebral small vessel disease by haploinsufficiency.
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COL4A1 haploinsufficiency causes cerebral small vessel disease and capillary basement membrane thickening.
"a clear reduction of COL4A1 protein expression were demonstrated, indicating haploinsufficiency of COL4A1"
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Collagen Fibril Assembly and Function.
Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB).
Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
Collagen type IV degradation by MMP2,3,4,9,10,12
Procollagen triple helix formation
Formation of collagen networks
Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1
FN1 binds Collagen types I-V, VII
DDR1 binds collagen type I, II, III, IV, V, XI fibrils
Collagen type VII binds laminin-322 and collagen IV
Laminins:Nidogens binds collagen type IV networks
Collagen type IV sulfilimine cross-linking by peroxidasin
Interaction of NCAM1 with collagens
PDGF binds to extracellular matrix proteins
Arresten binds integrin alpha1beta1
Association of procollagen type IV
Collagen VII binds collagen IV
Dynamics of genomic innovation in the unicellular ancestry of animals.
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The filasterean Ministeria vibrans, a unicellular amoeba without basement membrane or ECM, has a canonical type IV collagen gene, the only one known outside animals.
"a canonical type IV collagen gene in the filasterean Ministeria vibrans"
A unicellular relative links aggregative multicellularity to animal origins.
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Ministeria vibrans upregulates its alpha type IV collagen, with other ECM genes, during cell aggregation.
"Diverse ECM-related genes were also upregulated, including alpha type IV collagen"
Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues.
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Collagen IV is absent from unicellular sister groups of animals (choanoflagellates, filastereans, amoebozoans, apusozoans).
"do not contain collagen IV as determined by genomic analyses"
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Collagen IV and basement membranes are present in ctenophores, placozoans and homoscleromorph sponges; demosponges and hexactinellids lack both.
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Homoscleromorph sponges have basement membranes with collagen IV.
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Choanoflagellates have collagenous GXY repeats and laminin-like domains but no complete ECM components.
A unique covalent bond in basement membrane is a primordial innovation for tissue evolution.
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The sulfilimine cross-link of collagen IV, made by peroxidasin, is conserved throughout Eumetazoa and arose at the Porifera-Cnidaria divergence.
"the cross-link is conserved throughout Eumetazoa and arose at the divergence of Porifera and Cnidaria over 500 Mya"
Anti-angiogenic cues from vascular basement membrane collagen.
Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressor.
Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin.
Human α1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by α1β1 integrin.
Type I collagen gel modulates extracellular matrix synthesis and deposition by tracheal epithelial cells.