Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid.
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Pld-null flies have strongly reduced light sensitivity and heightened susceptibility to retinal degeneration. Pld supports phototransduction by maintaining PIP2 rather than by being light-activated.
"Pld(null) flies exhibit decreased light sensitivity as well as a heightened susceptibility to retinal degeneration."
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Pld localizes to the photoreceptor cell body and the base of the rhabdomere.
"Pld was detected in the photoreceptor cell body and at the base of the rhabdomere"
A role for Phospholipase D in Drosophila embryonic cellularization.
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Drosophila Pld is a bona fide PLD stimulated by receptor signaling and ARF1, and the H1095N HKD2 mutant is inactive.
"Taken together, these findings demonstrate that Pld is a bona fide PLD and can be regulated by ARF GTPases"
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Pld localizes to small cytoplasmic vesicles in cellularizing embryos. Its loss alters Golgi-derived vesicle size and blocks plasma membrane insertion of Neurotactin.
"chronic Pld deficiency causes abnormal Golgi structure and secretory vesicle trafficking."
Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling.
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The dPLD3.1 null has no detectable in vivo PLD activity and reduced retinal PA. Catalytically active Pld rescues retinal degeneration and rhodopsin-vesicle accumulation.
"These phenotypes were associated with reduced levels of phosphatidic acid, the product of PLD activity and were rescued by reconstitution with catalytically active PLD."
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Enhanced Pld activity clears endocytosed rhodopsin vesicles in a retromer- and Arf1-dependent manner.
"enhanced PLD activity was sufficient to clear RLVs from the cell body by a process dependent on Arf1-GTP levels and retromer complex function."