CILK1 (ICK) notes

Deep research: not run. In this environment falcon times out after 600 s and perplexity-lite is not
installed. The review uses the cached GOA-cited publications, PMID:24853502 and the UniProt record.
CILK1 is the human ortholog of C. elegans DYF-5 and Chlamydomonas LF4.

Key points

• Kinase for KIF3A at the ciliary tip. PMID:24797473
• IFT turnaround. PMID:24797473
• Cilium length control. PMID:24853502
• ECO syndrome R272Q. PMID:19185282

Curation decisions

• Nucleus rows (GFP overexpression) and generic signal transduction rows are kept as non-core.
  HSP90/FKBP5/SMYD2 protein binding rows are removed.
• The IFT process rows were accepted, consistent with the DYF-5 ortholog review. CILK1's role is
  regulatory (it acts on the motor), and whether regulation terms (GO:1905796/GO:1905799) would be
  more accurate is raised as a suggested question. No NEW cilium-length term was added, because
  loss-of-function phenotypes differ by cell type (elongation versus impaired ciliogenesis).