Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Hepcidin, a urinary antimicrobial peptide synthesized in the liver.
Truncated brush border myosin I affects membrane traffic in polarized epithelial cells.
Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells.
Myo6 facilitates the translocation of endocytic vesicles from cell peripheries.
Mechanism for multiple ligand recognition by the human transferrin receptor.
The human plasma proteome: a nonredundant list developed by combination of four separate sources.
Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment.
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes.
Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells.
Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment.
The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin.
Release of the soluble transferrin receptor is directly regulated by binding of its ligand ferritransferrin.
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron.
A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Ebola virus uses clathrin-mediated endocytosis as an entry pathway.
Structural basis for iron piracy by pathogenic Neisseria.
The structural basis of transferrin sequestration by transferrin-binding protein B.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.
CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression.
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.
Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms.
A reference map of the human binary protein interactome.
Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation.
The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.
Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor.
Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum.
Release of platelet secretory granule components
TFR2 dimer binds 2xholoTF
AP-2 directly binds some endocytic cargo
F- and N- BAR domain proteins bind the clathrin-coated pit
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
Clathrin recruits PIK3C2A
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2
FAM20C phosphorylates FAM20C substrates
holoTF:TFRC dimer translocates from plasma membrane to endosome membrane
apoTF:TFRC dimer translocates from endosome membrane to plasma membrane
Fe3+ dissociates from holoTF:TFRC dimer
apo-Transferrin dissociates from the receptor complex
apoTF binds 2Fe3+ to form holoTF
TFRC dimer binds 2xholoTF
UniProt record P02787 (TRFE_HUMAN)