Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
The C. elegans orthologue ceBNIP3 interacts with CED-9 and CED-3 but kills through a BH3- and caspase-independent mechanism.
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DCT-1/ceBNIP3 interacts with CED-9 and CED-3
"ceBNIP3 protein interacts with CED-9 and BCL-XL"
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Forms homodimers via transmembrane domain
"ceBNIP3 is expressed primarily as a 25 kDa monomer and a 50 kDa homodimer"
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Localizes to mitochondria via C-terminal TM domain
"the TM domain of ceBNIP3 mediates the localization of the protein to mitochondria"
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Kills through BH3- and caspase-independent mechanism
"ceBNIP3 kills mammalian cells by a caspase-independent mechanism"
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Degraded by ubiquitin-proteasome pathway
"ceBNIP3 protein is rapidly degraded through a ubiquitin-dependent pathway by the proteasome"
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.
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dct-1 is a direct DAF-16 target gene
"We cloned 103 target sequences containing consensus DAF-16 binding sites"
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DAF-16 target genes affect lifespan
"inactivation of more than half of these genes significantly altered DAF-16-dependent functions, including life span"
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans.
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DCT-1 is the C. elegans BNIP3/NIX homolog and key mediator of mitophagy
"We find that DCT-1 is a key mediator of mitophagy and longevity assurance under conditions of stress in C. elegans"
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Impairment of mitophagy compromises stress resistance
"Impairment of mitophagy compromises stress resistance and triggers mitochondrial retrograde signalling"
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SKN-1 regulates DCT-1 expression
"mitophagy by enhancing DCT-1 expression"
Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog.
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ceBNIP3 complexes with CED-9
"ceBNIP3 complexes with CED-9, the worm homolog of BCL-2"
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Heterodimerizes with proCED-3 via prodomain
"CeBNIP3 also efficiently heterodimerizes with the cell death protease proCED-3 by direct binding via the prodomain"
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Forms ternary complex with CED-9 and CED-3
"In cells coexpressing CED-9, ceBNIP3 and CED-3, all three proteins exist as a ternary complex"
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May initiate apoptosis by recruiting CED-3 to mitochondria
"ceBNIP3 may be a novel component of the C. elegans apoptosis paradigm and may initiate apoptosis by recruiting CED-3 to mitochondria"
Deep research review of DCT-1 function
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DCT-1 is an outer mitochondrial membrane mitophagy receptor
"DCT-1 is an integral OMM protein"
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Contains LIR-like WXXL motif for LGG-1 binding
"DCT-1 carries characteristic features of BNIP3-family mitophagy receptors, including a conserved WXXL motif"
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Works in pathway with PINK-1 and PDR-1
"DCT-1 functions in concert with the PINK-1–PDR-1 (Parkin) ubiquitin pathway"