PTCD3 review notes

Deep research

Automated deep research could not be generated: just deep-research-falcon failed
(Edison API 402 Payment Required; perplexity-lite fallback unavailable) and
just deep-research-openai failed with 401. The review uses cached literature and the
UniProt record directly.

Literature used

• Davies et al. 2009 [PMID:19427859 "showed that it is a mitochondrial protein that associates with the small subunit of mitochondrial ribosomes"; "lowering PTCD3 in 143B osteosarcoma cells decreased mitochondrial protein synthesis"] (abstract only).
• Borna et al. 2019, COXPD51 [PMID:30607703 "PTCD3, a member of the pentatricopeptide repeat domain protein family, is a component of the small mitoribosomal subunit"; "Quantitative proteomic analysis revealed decreased levels of the small mitoribosomal subunits"].
• Aibara et al. 2020 human mitoribosome translation structures PMID:32812867.
• LRPPRC-SLIRP mitoribosome structure 2024 PMID:39134711.

Curation decisions

• ribosomal small subunit binding (IDA/IBA/IEA) modified to structural constituent of ribosome: PTCD3 is now an established integral mitoribosomal protein (mS39), not a
  peripheral subunit-binding factor. The MRPS15 co-IP protein binding row from the same
  paper is modified to the same term; other protein binding rows (LNX2 Y2H, BioPlex,
  pestivirus Npro) removed.
• Mitochondrial inner membrane kept as non-core (whole-mitoribosome association).
• The mitochondrial matrix IDA (PMID:23275553) is accepted without a quote because the
  cached abstract does not mention PTCD3.

Disease context (dismech)

dismech Combined_Oxidative_Phosphorylation_Deficiency_51 used only as a literature lead.