Falcon deep research report for HSPA1B
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Control of mRNA decay by heat shock-ubiquitin-proteasome pathway.
Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes.
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.
BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species.
TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase.
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation.
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain.
Molecular composition of IMP1 ribonucleoprotein granules.
Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly.
Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function.
The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.
Stress-induced localization of HSPA6 (HSP70B') and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells.
The role of oxidative stress in Parkinson's disease.
Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease.
RING finger protein RNF207, a novel regulator of cardiac excitation.
A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.
HSP70 regulates the function of mitotic centrosomes.
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein
HSF1 acetylation at Lys80
HSP70 binds to HSP40:nascent protein
HSF1-mediated gene expression
Acetylated HSF1 dissociates from DNA
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm
HSP110s exchange ATP for ADP on HSP70s:ADP
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein
ATP binding to HSP90 triggers conformation change
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein
Exocytosis of ficolin-rich granule lumen proteins
FA core complex:HSP70s binds PKR
Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1
HSP70 and Primary Arterial Hypertension
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Comprehensive review of HSP70 domain architecture (NBD, SBD, C-terminal tail), co-chaperone dependence (HSP40/DnaJ, HSP90), and role in proteostasis and stress adaptation. Notes stress-induced HSP70 expression can reach up to 15% of cellular protein.
Diversity of extracellular HSP70 in cancer - advancing from a molecular biomarker to a novel therapeutic target
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HSPA1B is among HSP70 family members reported on the plasma membrane and in exosomes. Extracellular HSP70 can be actively trafficked through secretory granules, ABC transporter-mediated endolysosomal translocation, and exosome/ ectosome release. Membrane association involves phosphatidylserine binding, oligomerization, and enrichment in lipid rafts.
Is It Still Possible to Think about HSP70 as a Therapeutic Target in Onco-Hematological Diseases?