DPH5 (YLR172C, P32469) notes

Module diphthamide_biosynthesis, step 2 (EC 2.1.1.314).

• SAM:EF-2 methyltransferase PMID:3042777; gene cloned, recombinant protein active PMID:1508200.
• Product is diphthine methyl ester PMID:24739148; archaeal Dph5 differs PMID:24739148.

Observations: YeastPathways/GO-CAM uses GO:0004164 diphthine synthase (GO taxon constraint: Archaea) for three single-methyl steps ending at diphthine; MODIFY to GO:0141133 diphthine methyl ester synthase activity. Product of YeastCyc RXN-11373 should be diphthine methyl ester.