GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000118

TreeGrafter-generated GO annotations

TreeGrafter supplied cytosol, broad deaminase, and guanine-metabolism annotations.

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

Combined automated methods supplied the exact guanine-deaminase activity and catabolic-process annotations.

file:PSEPK/guaD/guaD-uniprot.txt

UniProtKB entry for Pseudomonas putida KT2440 GuaD (Q88F18)

UniProt assigns guanine deamination to xanthine and a zinc cofactor by automated rules.

"Reaction=guanine + H2O + H(+) = xanthine + NH4(+);"

file:interpro/panther/PTHR11271/PTHR11271-paint.tsv

PANTHER PTHR11271 PAINT annotations

PTN000138455 carries guanine deaminase activity propagated from characterized ortholog seeds.

"PTHR11271 PTN000138455 GO:0008892"

PMID:26355499

Identification of a chemoreceptor that specifically mediates chemotaxis toward metabolizable purine derivatives.

KT2440 can use guanine and other purine derivatives as sole nitrogen sources.

"permitting their use as sole nitrogen sources"

file:PSEPK/guaD/guaD-deep-research-openscientist.md

OpenScientist deep-research report for Pseudomonas putida KT2440 guaD

The report identifies the target as guanine deaminase while explicitly acknowledging the absence of target-specific enzymology.

"No direct enzymology on the KT2440 protein."