Gene Ontology annotation through association of InterPro records with GO terms
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis.
-
CDK16 is activated by membrane-associated cyclin Y; cyclin binding needs the N-terminal extension and is inhibited by Ser153 phosphorylation.
"Thus, the N-terminal domain is required for CCNY binding and this interaction is controlled by phosphorylation of CDK16 on S153."
Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.
Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells.
Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis.
Cyclin-dependent kinase 5-dependent phosphorylation of Pctaire1 regulates dendrite development.
PP2A and CDK16 antagonistically regulate WIPI2B phosphorylation and neuronal autophagosome biogenesis.
Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.
Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.
Isoform comparison of blue whale CDK16 products with human CDK16