PNPT1 notes

Deep research could not be generated (falcon HTTP 402; perplexity-lite unavailable;
openai key rejected). The review uses the cached literature and UniProt.

• Degradosome: SUV3 dimer plus PNPase trimer degrade structured RNA PMID:19509288.
• In vivo complex in D-foci; a minor matrix pool of PNPase PMID:23221631.
• Bulk IMS pool PMID:16966381.
• mt-dsRNA restriction and interferon signalling (PMID:30046113); m5C/C1QBP recruitment (PMID:39019044); G4 RNA decay with GRSF1 (PMID:29967381).
• RNA import role (PMID:20691904), supported in COXPD13 fibroblasts (PMID:23084291) and the hearing-loss family (PMID:23084290), kept as non-core.
• Melanoma overexpression studies (c-myc, miR-221, senescence; PMID:12721301, PMID:16055741, PMID:16410805, PMID:20547861) treated as non-core or over-annotation.

Claude Code deep research (2026-10-14)

PNPT1-deep-research-claude-code.md was produced by just deep-research-claude-code human PNPT1. In two separate runs the provider answered in a single turn with no web search (run_metadata has no web_search_requests), so its references come from the model's own knowledge and were not retrieved. Treat its citations as unverified leads; nothing in the review rests on them.

2026-11-11 cross-reference: GO:0000175 and the PNPase family

The PNPase family review (interpro/panther/PTHR11252/PTHR11252-review.yaml)
leaves GO:0000175 (3'-5'-RNA exonuclease activity) UNRESOLVED. GO places the term
under GO:0016896 (hydrolysis yielding 5'-phosphomonoesters), whereas PNPase is
phosphorolytic. The bacterial pnp reviews (ECOLI, PSEPK) modify the term to
GO:0004654, while this review accepts it as core. The verdicts here are left
unchanged pending a GO decision, recorded as a suggested question.