Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9.
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
A soluble version of the receptor-like protein tyrosine phosphatase kappa stimulates neurite outgrowth via a Grb2/MEK1-dependent signaling cascade.
Three new types of Apaf-1 in mammalian cells.
Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.
A mutational epitope for cytochrome C binding to the apoptosis protease activation factor-1.
CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
Analysis of APAF-1 expression in human cutaneous melanoma progression.
p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway.
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
No death without life: vital functions of apoptotic effectors.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer.
Structure of an apoptosome-procaspase-9 CARD complex.
Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP.
The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3.
Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis.
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.
Cleavage of Procaspase-3 by the apoptosome
CYCS:APAF1 binds procaspase-9
Cleavage of Procaspase‑9 to caspase‑9
Cleavage of Procaspase-7 by the apoptosome
TP53 stimulates APAF1 gene expression
Exocytosis of secretory granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6
CASP9 is phosphorylated at T412
Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.
Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.