CEM1 (YER061C, P39525) notes

• Mitochondrial beta-ketoacyl-ACP synthase (KAS, EC 2.3.1.41) of the type II mitochondrial FAS (mtFAS) [UniProt:P39525 "Reaction=a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP]"]; mitochondrial location by HTP [UniProt:P39525].
• cem1 null is respiratory deficient with low lipoic acid; rescued by human OXSM PMID:15668256.
• mtFAS context PMID:9388293; human ortholog elongates C2-C14 acyl-ACP PMID:15668256.
• YeastPathways assigns Cem1 to cytosolic FAS pathways (initial steps, stearate III fungi, elongation, superpathways) - these reactions in the cytosol are carried out by the FAS2 KS domain; cytosol RCA rows are wrong. The KAS activity itself is right.
• Elongation/stearate rows: product of mtFAS is mainly octanoyl-ACP (lipoate precursor), so "fatty acid elongation, saturated fatty acid" (from stearate superpathway) is an over-annotation.