Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt.
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation.
The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes.
A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells.
Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death.
The protooncogene TCL1 is an Akt kinase coactivator.
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1.
Visualization of biochemical networks in living cells.
Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.
Binding of protein kinase B to the plakin family member periplakin.
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver.
Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.
The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.
Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A.
Akt/PKB regulates actin organization and cell motility via Girdin/APE.
A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus.
Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function.
Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha.
Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor.
Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor.
Kinetic mechanism of AKT/PKB enzyme family.
Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway.
A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle.
Regulation of TopBP1 oligomerization by Akt/PKB for cell survival.
BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites.
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.
Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression.
Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses.
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.
A beta-arrestin 2 signaling complex mediates lithium action on behavior.
Akt and CHIP coregulate tau degradation through coordinated interactions.
A pathway sensor for genome-wide screens of intracellular proteolytic cleavage.
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AKT1 knockdown enhanced LC3 reporter release, consistent with AKT1 acting as a negative regulator of autophagy.
"Knockdown of AKT1 resulted in an increase of dNGLUC release from cells expressing Actin-LC3-dNGLUC compared to vector control"
Synthesis and structure based optimization of novel Akt inhibitors.
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Human AKT1 inhibitor/substrate-peptide structures (PDB 3CQU and 3CQW) provide direct structural context for the kinase active site and drug interactions.
"X-ray co-crystal structures of two lead series results in the understanding of key binding interactions, the design of new lead series, and enhanced potency."
UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes.
p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.
Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells.
Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY.
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis.
Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification.
PTEN regulation by Akt-EGR1-ARF-PTEN axis.
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts.
Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells.
14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF).
Regulation of human myoblast differentiation by PEBP4.
PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt.
c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms.
Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses.
EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt.
Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.
Evidence for the involvement of FAM110C protein in cell spreading and migration.
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis.
DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis.
The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration.
A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation.
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.
Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt.
Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation.
COMMD1 downregulates the epithelial sodium channel through Nedd4-2.
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair.
Degradation of HER2/neu by ANT2 shRNA suppresses migration and invasiveness of breast cancer cells.
Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation.
Vimentin is a novel AKT1 target mediating motility and invasion.
Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis.
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.
A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.
A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2.
Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation.
Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2.
Akt1 and Akt2: differentiating the aktion.
Bimodal regulation of FoxO3 by AKT and 14-3-3.
LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations.
A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health.
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.
Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation.
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.
ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.
Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling.
NOK/STYK1 interacts with GSK-3β and mediates Ser9 phosphorylation through activated Akt.
Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation.
Microarray-assisted pathway analysis identifies MT1X & NFκB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma.
BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.
MOZ increases p53 acetylation and premature senescence through its complex formation with PML.
Akt kinase targets the association of CBP with histone H3 to regulate the acetylation of lysine K18.
SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradation.
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AKT-mediated Rac1 phosphorylation supports FBXL19-mediated Rac1 ubiquitination and degradation.
"Protein kinase AKT-mediated phosphorylation of Rac1 at serine(71) was essential for FBXL19-mediated Rac1 ubiquitination and depletion."
FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies.
Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells.
IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway.
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PI3K-AKT-MTORC1 effects on autophagy are context dependent in detachment-induced autophagy models.
"enforced activation of this pathway is not sufficient to suppress detachment-induced autophagy in MECs."
Hexokinase activity is required for recruitment of parkin to depolarized mitochondria.
Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia.
Charting the molecular links between driver and susceptibility genes in colorectal cancer.
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer.
Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Widespread macromolecular interaction perturbations in human genetic disorders.
Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy.
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Lysosomal Akt1 negatively regulates chaperone-mediated autophagy.
"Overall, these results support an inhibitory effect of Akt1 on CMA"
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AKT1 regulates LAMP-2A translocation-complex dynamics through lysosomal GFAP phosphorylation.
"purified GFAP become phosphorylated upon incubation with not only cytosolic but also lysosomal Akt"
The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation.
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Regulation of Serine-Threonine Kinase Akt Activation by NAD(+)-Dependent Deacetylase SIRT7.
Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease.
Roles of tau protein in health and disease.
Architecture of the human interactome defines protein communities and disease networks.
ATP2B1 gene Silencing Increases Insulin Sensitivity through Facilitating Akt Activation via the Ca(2+)/calmodulin Signaling Pathway and Ca(2+)-associated eNOS Activation in Endothelial Cells.
Degradation of FBXO31 by APC/C is regulated by AKT- and ATM-mediated phosphorylation.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca(2+) levels and tumor growth.
Ubiquitination of Rheb governs growth factor-induced mTORC1 activation.
Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.
The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
A growth-factor-activated lysosomal K(+) channel regulates Parkinson's pathology.
RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT.
Protein kinase B/AKT phosphorylates hypoxia-inducible factor-3α1 in response to insulin, promoting cell growth and migration.
m(6)A-Mediated TMCO3 Promotes Hepatocellular Carcinoma Progression by Facilitating the Membrane Translocation and Activation of AKT.
AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation.
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation.
Mechanism of activation of protein kinase B by insulin and IGF-1.
Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216.
Phosphorylation of USP8 by P-AKT
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
BH2 binding can lead to eNOS uncoupling
Uncoupled eNOS favours the formation of superoxide
PDPK1 phosphorylates AKT at T308
AKT phosphorylates TSC2, inhibiting it
AKT phosphorylates IKKalpha
AKT phosphorylates p21Cip1 and p27Kip1
AKT phosphorylates caspase-9
mTORC2 phosphorylates AKT at S473
AKT phosphorylates FOXO transcription factors
PHLPP dephosphorylates S473 in AKT
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
AKT can phosphorylate RSK
AKT can phosphorylate NR4A1 (NUR77)
AKT phosphorylates AKT1S1 (PRAS40)
AKT1 binds eNOS complex via HSP90
AKT-mediated inactivation of FOXO1A
AKT phosphorylates FOXO1A
AKT1 E17K mutant binds PIP2
PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1
AKT1 E17K mutant is phosphorylated by TORC2 complex
PDPK1 phosphorylates AKT1 E17K mutant
Cellular responses to stress
PIP3 recruits AKT to the membrane
AKT1 E17K mutant phosphorylates BAD
AKT1 E17K mutant phosphorylates GSK3
AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1
AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)
AKT1 E17K mutant phosphorylates MDM2
AKT1 E17K mutant phosphorylates TSC2, inhibiting it
AKT1 E17K mutant phosphorylates caspase-9
AKT1 E17K mutant phosphorylates NR4A1 (NUR77)
AKT1 E17K mutant phosphorylates forkhead box transcription factors
AKT1 E17K mutant phosphorylates CREB1
AKT1 E17K mutant translocates to the nucleus
AKT1 E17K mutant phosphorylates RSK
AKT1 E17K mutant phosphorylates CHUK (IKKalpha)
AKT inhibitors block AKT membrane recruitment
Activated AKT phosphorylates AKT1S1 (PRAS40)
AKT interacts and phosphorylates Cot
Dephosphorylation of AKT by PP2A
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Protein Kinase B/Akt phosphorylates BRF1
Protein Kinase B (AKT) phosphorylates KSRP
KSRP (KHSRP) binds and destabilizes mRNA
Expression of STAT3-upregulated cytosolic proteins
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
AKT1 dephosphorylation by PP2A-B56-beta,gamma
Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
PIP3 recruits PDK1 and AKT to the membrane
AKT1 phosphorylates NOTCH4
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
AKT phosphorylates FOXO3 downstream of FLT3
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species
p-S473-AKT1 phosphorylates ESR1 on serine-167
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
p-T816-PKN2 phosphorylates AKT1 on serine-308
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177
mTORC2 phosphorylates AKT1 on serine-473
Activated AKT1 phosphorylates Runx2
UniProt text export for AKT1
Falcon deep research report for AKT1
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The genuine Falcon report provides secondary background on AKT1 signaling; primary evidence supplies the reviewed core functions.
"AKT1 is a **serine/threonine protein kinase** (PKB) that is activated downstream of receptor tyrosine kinases (RTKs), GPCRs, and insulin receptor substrates (IRS) via PI3K lipid signaling."
Proteostasis PN projected gene GO summary
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The PN projection maps AKT1 to negative regulation of chaperone-mediated autophagy as a more specific term than existing GOA.
"AKT1 GO:1904715 negative regulation of chaperone-mediated autophagy more_specific_than_existing_goa"
Proteostasis PN autophagy-lysosome pathway mappings
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The PN CMA inhibitor type maps to negative regulation of chaperone-mediated autophagy, while the LAMP2A multimerization subtype is contextual.
"This PN type explicitly records inhibitory roles for CMA."
Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.
Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells.
FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress.
Akt activation prevents Apop-1-induced death of cells.
Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes.
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.
AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1.
Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions.
Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.
Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway.
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation.
Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2.
The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling.
Hyperactive Akt-mTOR pathway as a therapeutic target for pain hypersensitivity in Cntnap2-deficient mice.
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells.
Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport.