Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans.
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gsk-3 null mutants have a shortened lifespan and are not further extended by lithium.
"Exposure of gsk-3β(nr2047) mutants to Li + causes a further, but slight 7% decrease in median lifespan"
A beta-catenin-dependent Wnt pathway mediates anteroposterior axon guidance in C. elegans motor neurons.
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gsk-3 mutants have D-type motor neuron axon guidance defects as part of a beta-catenin-dependent Wnt pathway.
"Downstream of Wnt/Fz, we find that mutants for mig-5/Dsh, gsk-3, pry-1/Axin and bar-1/β-catenin also show D-type axon guidance defects, suggesting that Wnt-mediated axon guidance can be transduced through a β-catenin-dependent pathway."
UniProt entry Q9U2Q9 (gsk-3)
WormBase gene description for gsk-3 (worm)
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell.
The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans.
DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegans.
The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans.
Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development.
Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans.
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network.
Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development.
The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.
Wnt and CDK-1 regulate cortical release of WRM-1/β-catenin to control cell division orientation in early Caenorhabditis elegans embryos.
A combined binary interaction and phenotypic map of C. elegans cell polarity proteins.
Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3.
Restriction of mesendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3beta homolog is mediated by MED-1 and -2 in C. elegans.
Sperm-specific glycogen synthase kinase 3 is required for sperm motility and the post-fertilization signal for female meiosis II in Caenorhabditis elegans.