pis1 (SPAC1D4.08, UniProt Q10153) notes
- PI synthase, CDP-alcohol phosphatidyltransferase family (PTHR15362:SF4) [UniProt:Q10153 "Catalyzes the synthesis of phosphatidylinositol (PtdIns)."].
- Only S. pombe experimental data are 1992 extract measurements (pre-cloning): "Upon the addition of inositol to inositol-starved cells, there was a rapid and continued increase in PI synthase expression." PMID:1324908 (abstract-only).
- All locations (ER, Golgi, mitochondrial outer membrane) are by similarity to S. cerevisiae Pis1 (P06197) [UniProt:Q10153]. ER accepted as core; Golgi and MOM kept as non-core.
- Difference from S. cerevisiae PIS1 review: there, Golgi and mitochondrial outer membrane are accepted as core locations on S. cerevisiae experimental data; for S. pombe they are homology-only and kept non-core.
- GO-CAM 663d668500002178 (PI/PIP biosynthesis): pis1 GO:0003881 in ER membrane, part_of GO:0006661. Consistent. This model is cited in the module annoton but is missing from the module-level gocam_associations list.