Cyclic di-AMP impairs potassium uptake mediated by a cyclic di-AMP binding protein in Streptococcus pneumoniae.
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CabP directly interacts with the potassium transporter SPD_0076.
"we showed that CabP
directly interacted with a potassium transporter (SPD_0076) and that both
proteins were required for pneumococcal growth in media with low concentrations
of potassium."
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CabP specifically recognizes cyclic di-AMP.
"We demonstrated that CabP specifically bound c-di-AMP"
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Elevated c-di-AMP weakens the interaction and potassium uptake.
"the interaction between CabP and SPD_0076 and the
efficiency of potassium uptake were impaired by elevated c-di-AMP in
pneumococci."