Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
Characterization of the Drosophila melanogaster mitochondrial proteome.
An inventory of peroxisomal proteins and pathways in Drosophila melanogaster.
Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH).
-
A single Drosophila IDH gene encodes cytosolic and mitochondrial isoforms; Idh mutants have reduced IDH activity and NADPH/NADP+ ratio, accumulate ROS and are rotenone-sensitive; Idh overexpression protects DJ-1 mutant dopaminergic neurons.
"From these results, we concluded that IDH is an important antioxidant enzyme that protects cells downstream of DJ-1 under oxidative stress."
Alpha-ketoglutarate supplementation in long-lived Drosophila melanogaster: Impact on lifespan and metabolic responses.
Properties of Drosophila NADP+-isocitrate dehydrogenase purified on Procion Brilliant Blue-Sepharose-4B
UniProtKB B7Z0E0 (Idh, Drosophila melanogaster) TrEMBL record
IDH2-mediated regulation of the biogenesis of the oxidative phosphorylation system.
-
Muscle-specific Idh (dIDH2, CG7176) knockdown raises the NADP+:NADPH ratio, impairs respiratory complex I assembly and triggers ferroptotic signals; CG7176 is the sole fly ortholog of IDH1 and IDH2.
"CG7176 (dIDH2) is the sole Drosophila ortholog of both IDH1 and IDH2, suggesting that it could function in the cytosol, peroxisome, and/or mitochondrion."
FlyBase gene description for Idh (DROME)