Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels.
Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis.
Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.
Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth.
Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress.
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Nrdp1 ubiquitinates Parkin (poly-Ub chains in vitro and in cells), promoting its proteasome-dependent degradation, lowering Parkin activity and increasing ROS; Parkin abrogates Nrdp1-induced oxidative stress.
Next-generation sequencing to generate interactome datasets.
Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Protein microarray characterization of the S-nitrosoproteome.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3.
Architecture of the human interactome defines protein communities and disease networks.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
Self-ubiquitination of RNF41
RNF41 ubiquitinates ERBB3
RNF41 ubiquitinates activated ERBB3
Deubiquitination of RNF41 by P-USP8
Ubiquitinated RNF41 binds P-USP8
RNF41 binds neuregulin-activated ERBB3
ERBB3 binds RNF41 ubiquitin ligase