Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

PMID:23572552

ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.

A PI4KB N-terminal helix mutation abolishes binding to C10orf76/ARMH3.

"Mutant QE65AA abrogated binding of PI4KB to C10orf76 and Rab11B but increased binding to ACBD3 by 6-fold."

PMID:31519766

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.

ARMH3 binds GBF1 and is needed for Golgi maintenance.

"Knockdown studies revealed C10orf76 to be involved in Golgi maintenance."

PMID:39580461

ARMH3 is an ARL5 effector that promotes PI4KB-catalyzed PI4P synthesis at the trans-Golgi network.

ARMH3 is an ARL5 effector that activates PI4KB at the TGN.

"Using proximity biotinylation and protein interaction assays, we found that the armadillo-repeat protein ARMH3 (C10orf76) binds to active, but not inactive, ARL5, and that it is recruited to the TGN in a SYS1-ARFRP1-ARL5-dependent manner."

PMID:36921576

ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.

ARMH3 recruits PI4KB to direct STING Golgi-to-endosome trafficking.

"Upon cGAMP-triggered translocation, ARMH3 interacted with STING at the Golgi and recruited phosphatidylinositol 4-kinase beta (PI4KB) to synthesize PI4P, which directed STING Golgi-to-endosome trafficking via PI4P-binding proteins AP-1 and GGA2."

PMID:31829496

Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication.

ARMH3 binds the PI4KB kinase linker.

"We used hydrogen-deuterium exchange mass spectrometry to characterize the c10orf76-PI4KB complex and reveal that binding is mediated by the kinase linker of PI4KB, with formation of the heterodimeric complex modulated by PKA-dependent phosphorylation."

PMID:37195633

The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi.

The ARMH3-PI4KB axis supplies the PI4P that CERT uses at the distal Golgi.

"C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi."

file:human/ARMH3/ARMH3-uniprot.txt

UniProt entry Q5T2E6 (ARMD3_HUMAN)

file:human/ARMH3/ARMH3-deep-research-affinage.md

Affinage mechanistic annotation for ARMH3 (human)