Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif.
TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.
The structural basis for the recognition of diverse receptor sequences by TRAF2.
TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton.
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.
A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress.
A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains.
Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling.
A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis.
Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling.
T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and AP-1 without TNF stimulation.
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.
TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB.
Roles of CHOP/GADD153 in endoplasmic reticulum stress.
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
TRAF family proteins link PKR with NF-kappa B activation.
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase.
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs.
TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination.
Towards a proteome-scale map of the human protein-protein interaction network.
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases.
The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signalling.
Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals.
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling.
RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation.
PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.
Unconventional ligand activation of herpesvirus entry mediator signals cell survival.
CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1.
Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agents.
Asymmetric recruitment of cIAPs by TRAF2.
Network organization of the human autophagy system.
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88.
The MYND domain-containing protein BRAM1 inhibits lymphotoxin beta receptor-mediated signaling through affecting receptor oligomerization.
Solution of the structure of the TNF-TNFR2 complex.
NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling.
Next-generation sequencing to generate interactome datasets.
TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8.
Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.
AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Toward an understanding of the protein interaction network of the human liver.
The unfolded protein response: integrating stress signals through the stress sensor IRE1α.
Arginine methylation-dependent regulation of ASK1 signaling by PRMT1.
The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor.
Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells.
Protein interactions of the transcription factor Hoxa1.
NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-κB activation.
EVER2 protein binds TRADD to promote TNF-α-induced apoptosis.
OTUB1 modulates c-IAP1 stability to regulate signalling pathways.
Rotavirus NSP1 inhibits interferon induced non-canonical NFκB activation by interacting with TNF receptor associated factor 2.
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades.
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.
A proteome-scale map of the human interactome network.
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.
Widespread macromolecular interaction perturbations in human genetic disorders.
Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.
Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.
Helicobacter pylori induces direct activation of the lymphotoxin beta receptor and non-canonical nuclear factor-kappa B signaling.
TRAF-interacting protein with forkhead-associated domain (TIFA) transduces DNA damage-induced activation of NF-κB.
RANK-c attenuates aggressive properties of ER-negative breast cancer by inhibiting NF-κB activation and EGFR signaling.
PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
Haploinsufficiency of A20 impairs protein-protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation.
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.
A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF.
The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Quantitative fragmentomics allow affinity mapping of interactomes.
Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics.
A proteome-scale map of the SARS-CoV-2-human contactome.
Death by TNF: a road to inflammation.
Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.
Ubiquitination of gasdermin D N-terminal domain directs its membrane translocation and pore formation during pyroptosis.
Multimodal cell maps as a foundation for structural and functional genomics.
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.
Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins.
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.
ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.
4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.
The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.
Caspase-8 processing in the DISC
TRADD:TRAF2:RIP1 binds FADD
TNF-mediated dimerization of procaspase-8
FLIP(L) and procaspase-8 form heterodimer in TNF signaling
FLIP(S) and procaspase-8 form heterodimer
Caspase-8 and FLIP(L) processing at DISC
BIRC(cIAP1/2) ubiquitinates RIPK1
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
RIPK1 is cleaved by CASP8
K63polyUb-RIPK1 is deubiquitinated
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
CLIP3 and CYLD bind TNF signaling complex
TRAF1 binds TRAF2 within TNFR1 signaling complex
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer
K63polyUb-cIAP1,2 ubiquitinates TRAF3
Protesomal degradation of K48polyUb-TRAF3
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
TRAF3:NIK binds TRAF2:cIAP1/2
FLIP(L) and procaspase-8 form heterodimer
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40
TRAF2:cIAP1/2 complex binds FN14:TWEAK
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
TRADD:TRAF2:RIP1:FADD binds pro-caspase 8
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
USP48 cleaves polyubiquitin
USP4 deubiquitinate TRAF2,TRAF6
Recruitment of TRAF6/TRAF2 to MAVS
Phosphorylation and release of IRF7
Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
Activation of IKK by MEKK1
Recruitment of TANK to TRAF6
Recruitment of IRF7 to TRAF6
RIPK1 variant is not cleaved by CASP8
Caspase-8 and FLIP(L) processing at TNFR signaling complex
RIPK1 is cleaved by CASP8:FLIP(L)
TBK1, IKBKE form homodimers
Phosphorylation of TBK1/IKBKE
TRAF2,6 ubiquitinates NLRC5
LUBAC ubiquitinates RIPK1 at K627
OPTN binds polyUb-RIPK1 within the TNFR1 complex
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2
MIB2 ubiquitinates RIPK1 at K377, K604, K634
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex
MAPKAPK2 phosphorylates RIPK1 at S320
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex
TBK1, IKBKE phosphorylate RIPK1 at T189
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex
CHUK, IKBKB phosphorylate RIPK1 at S25
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex
ULK1 phosphorylates RIPK1 at S357
OPTN recruits CYLD to the TNFR1 complex
Structural basis for the lack of E2 interaction in the RING domain of TRAF2.
CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.