age-1 (Q94125) review notes

Deep research: just deep-research-falcon worm age-1 --fallback perplexity-lite failed (falcon timed out / connection reset; perplexity provider unavailable in this environment). No deep-research file was produced; the review is based on cached publications, the UniProt record and PubMed lookups.

Key findings

• AGE-1 is the class I PI3K p110 catalytic subunit PMID:8700226
• PIP3 depends on AGE-1 PMID:23543623
• AGE-1 is cytoplasmic PMID:23543623
• PIP3 is made at the plasma membrane by AGE-1/AAP-1 PMID:25383666
• Dauer, lifespan, fertility outputs via DAF-16 PMID:9504918

Curation decisions

• GOA has only PI->PI3P (GO:0016303) and PI4P 3-kinase (GO:0035005) MF terms; the physiological class I activity GO:0046934 (PIP2 3-kinase, the term used in the DAF-2 module) is proposed as NEW (AGE-1 itself catalyses the step).
• PI3P biosynthetic process IBA marked over-annotated (class III / VPS34 function).
• Protein binding (AAP-1) -> PI3K regulatory subunit binding.
• Salt chemotaxis / learning / NMJ / stress rows kept as non-core cell-context outputs.
• Non-motile cilium IDA (PMID:16968739) is abstract-only; deferred to curator, non-core.