IDI1 notes (P15496, YPL117C)

• Type I IPP isomerase, IPP <-> DMAPP (EC 5.3.3.2) PMID:7908830.
• Purified from yeast, gene cloned PMID:2681212; active-site nucleophile Cys139 PMID:2223785; E207 essential PMID:7908830.
• Used with avian FPPS to make labelled FPP in vitro PMID:7858969.
• Cytoplasm/nucleus GFP PMID:14562095; cytosol SWAT-GFP PMID:26928762.
• Issues: vacuole NAS from Hu 2017 review -> MARK_AS_OVER_ANNOTATED; IPP biosynthesis IBA (plant-seeded) misrepresents yeast flux direction -> MARK_AS_OVER_ANNOTATED.
• Review: 21 ACCEPT, 3 KEEP_AS_NON_CORE, 2 MARK_AS_OVER_ANNOTATED, 1 MODIFY.