KAO2 (ent-kaurenoic acid oxidase, CYP88A4; At2g32440; UniProt Q9C5Y2) - curation notes

• Accession verified against UniProt (KAO2_ARATH).
• Falcon deep research attempted and failed (exit code 1).

Function

• ent-kaurenoic acid -> GA12 in three steps (RHEA:33219, EC 1.14.14.107) PMID:11172076
• KAO1/KAO2 redundant: single mutants wild-type, double mutant non-germinating GA dwarf PMID:25146977.

Location

• Leader sequence targets GFP to ER PMID:11722763.

Curation decisions

• Generic P450 MF terms -> MODIFY to GO:0051777.
• pollen tube development IBA (from rice KAO/RPE1): kept as non-core (downstream GA-dependent phenotype).
• KAO2 mitochondrion ISM (AtSubP) REMOVED: contradicted by ER GFP targeting and LOPIT.