Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Nucleotide sequence of bacteriophage lambda DNA.
Phage lambda CIII: a protease inhibitor regulating the lysis-lysogeny decision.
-
CIII forms oligomeric amphipathic alpha-helical structures and acts as a competitive protease inhibitor of host FtsH, preventing binding and degradation of the CII substrate.
"Here we show that the protease inhibitor CIII is present as oligomeric amphipathic alpha helical structures and functions as a competitive inhibitor of FtsH by preventing binding of the CII substrate."
Direct CIII-HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli sigma(32) by lambdaCIII.
-
Direct interaction between lambda CIII and Escherichia coli HflB (FtsH) inhibits FtsH-mediated proteolysis, stabilizing lambda CII (and host sigma32) and promoting lysogenic development.
"The CIII protein of bacteriophage lambda exhibits antiproteolytic activity against the ubiquitous metalloprotease HflB (FtsH) of Escherichia coli, thereby stabilizing the lambdaCII protein and promoting lysogenic development of the phage."