Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes.
c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development.
-
The three proteins participate in the transcriptional complex; binding directness remains as specified in the source assessment.
"c-Myb, GATA-3, and Menin form a core transcription complex"
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes.
GATA3 haplo-insufficiency causes human HDR syndrome.
Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction.
Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells.
-
GATA3 directly regulates endothelial Tie2 transcription, supporting its Ang1-dependent regulatory effects.
"GATA3 binds to and activates the Tie2 promoter"
GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells.
NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia.
MiR-573 inhibits prostate cancer metastasis by regulating epithelial-mesenchymal transition.
HDR syndrome: a novel "de novo" mutation in GATA3 gene.
A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome.
GATA3 is a master regulator of the transcriptional response to low-dose ionizing radiation in human keratinocytes.
Abundant expression of Kallikrein 1 gene in human keratinocytes was mediated by GATA3.
GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition.
T-bet, GATA-3, and Foxp3 expression and Th1/Th2 cytokine production in the clinical outcome of human infection with Leishmania (Viannia) species.
Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells.
Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3.
The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.
A T-cell specific TCR delta DNA binding protein is a member of the human GATA family.
Structure and expression of the human GATA3 gene.
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis.
Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
GATA3 inhibits GCM1 activity and trophoblast cell invasion.
GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA.
Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling.
ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1).
Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment.
ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators
ZFPM proteins bind GATA proteins
TCR-dependent translational control of GATA-3 enhances Th2 differentiation.
IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.
Transcription factor GATA-3 is essential for lens development.
Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene.
Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements.
Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation.
Notch directly regulates Gata3 expression during T helper 2 cell differentiation.
GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2.
GATA-3: an unexpected regulator of cell lineage determination in skin.
Lack of Gata3 results in conotruncal heart anomalies in mouse.
NFIA and GATA3 are crucial regulators of embryonic articular cartilage differentiation.
GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A) Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of Histone-3) Upregulates NCX3 (Na(+)-Ca(2+) Exchanger 3) Transcription and Contributes to Ischemic Preconditioning Neuroprotection.
GATA-3 expression in the development of anterior chamber associated immune deviation.
Acute and persisting Th2-like immune response after fractionated colorectal gamma-irradiation.
Common increase of GATA-3 level in PC-12 cells by three teratogens causing autism spectrum disorders.
Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture.
Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney.
Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.
Essential role of Gata transcription factors in sympathetic neuron development.
USP21 deubiquitinates GATA3,IL33
RUNX1 binds the core TAL1 complex
RUNX1-containing TAL1 complex binds the MYB gene enhancer
FOXA1 and GATA3 bind to CCND1 promoter
Binding of AP1 transcriptional activator complexes to CCND1 promoter
CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene
TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter
DDX5 binds ESR1:estrogen:TFF1 gene promoter
ESR1 binds to TFF1 gene promoter
FOXA1 and GATA3 bind TFF genes
ESR1:ESTG and EP300 are recruited to TFF3 promoter
Histone acetyltransferases are recruited to the TFF1 gene
PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene
Interaction of the pioneer transcription factor GATA3 with nucleosomes.
Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4.
A distal enhancer of GATA3 regulates Th2 differentiation and allergic inflammation.
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on curation of immunofluorescence data
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons.
Gata3 is a critical regulator of cochlear wiring.
Lymphodepletional strategies in transplantation.
Gata3 cooperates with Gcm2 and MafB to activate parathyroid hormone gene expression by interacting with SP1.
GATA3 Bioinformatics Analysis Results
-
GATA3 forms extensive protein-protein interaction networks with 126 high-confidence interactors including T-bet, EP300, STAT6, and FOXA1
-
GATA3 directly regulates 20 validated target genes across Th2 cytokines, T cell development, and epithelial function categories
Falcon deep research report on GATA3
GATA3 Deep Research Summary
Trans-acting T-cell-specific transcription factor GATA-3