Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms.
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KEAP1 identified in midbody proteome by mass spectrometry
"Midbodies were isolated from mammalian cells, proteins were identified by multidimensional protein identification technology (MudPIT)"
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
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KEAP1 functions as substrate adaptor for CUL3-dependent E3 ubiquitin ligase
"Keap1 functions as a substrate adaptor protein for a Cul3-dependent E3 ubiquitin ligase complex"
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KEAP1 assembles with CUL3 and RBX1 to target NRF2 for ubiquitination
"Keap1 assembles into a functional E3 ubiquitin ligase complex with Cul3 and Rbx1 that targets multiple lysine residues located in the N-terminal Neh2 domain of Nrf2 for ubiquitin conjugation"
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Cys151 is critical for KEAP1 function
"A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition"
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
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KEAP1 binds CUL3 via BTB domain and NRF2 via Kelch domain
"Here we report that the human BTB-Kelch protein Keap1, a negative regulator of the antioxidative transcription factor Nrf2, binds to CUL3 and Nrf2 via its BTB and Kelch domains, respectively"
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KEAP1-CUL3-ROC1 complex promotes NRF2 ubiquitination
"The KEAP1-CUL3-ROC1 complex promoted NRF2 ubiquitination in vitro"
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Knocking down KEAP1 or CUL3 results in NRF2 accumulation
"Blocking NRF2 degradation in cells expressing both KEAP1 and NRF2 by either inhibiting the proteasome activity or knocking down Cul3, resulted in NRF2 accumulation in the cytoplasm"
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
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KEAP1 is ubiquitinated by a CUL3-dependent complex
"Keap1 is a BTB-Kelch protein that functions as a substrate adaptor protein for a Cul3-dependent E3 ubiquitin ligase complex"
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Oxidative stress increases KEAP1 ubiquitination
"Ubiquitination of Keap1 is markedly increased in cells exposed to quinone-induced oxidative stress"
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KEAP1 degradation is proteasome-independent
"Degradation of Keap1 is independent of the 26 S proteasome, because inhibitors of the 26 S proteasome do not prevent loss of Keap1 following exposure of cells to quinone-induced oxidative stress"
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.
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DJ-1 stabilizes NRF2 by preventing KEAP1 association
"DJ-1 stabilizes Nrf2 by preventing association with its inhibitor protein, Keap1"
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KEAP1 promotes NRF2 ubiquitination
"DJ-1 stabilizes Nrf2 by preventing association with its inhibitor protein, Keap1, and Nrf2's subsequent ubiquitination"
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
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p62/SQSTM1 docks onto KEAP1 Kelch domain via KIR motif
"p62 docks directly onto the Kelch-repeat domain of Kelch-like ECH-associated protein 1 (KEAP1), via a motif designated the KEAP1 interacting region (KIR)"
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KEAP1-p62 interaction leads to KEAP1 accumulation in p62 bodies
"because p62 is polymeric the interaction between KEAP1 and p62 leads to accumulation of KEAP1 in p62 bodies"
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KEAP1 undergoes autophagic degradation via p62 interaction
"the interaction between KEAP1 and p62 leads to accumulation of KEAP1 in p62 bodies, which is followed by autophagic degradation of KEAP1"
Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation.
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Review on CRL3 complexes including KEAP1-containing complexes
"Based on studies about differentiation programs of mesenchymal stem cells (MSCs), including myogenesis, neurogenesis, chondrogenesis, osteogenesis and adipogenesis, we propose here that CRL3 complexes evolved to fulfill a pivotal role in mammalian cell differentiation"
UniProt entry for KEAP1
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Comprehensive functional annotation of KEAP1
"Component of the BCR(KEAP1) E3 ubiquitin ligase complex, at least composed of 2 molecules of CUL3, 2 molecules of KEAP1, and RBX1"
Towards a proteome-scale map of the human protein-protein interaction network.
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.
Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.
Defining the human deubiquitinating enzyme interaction landscape.
Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells.
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Network organization of the human autophagy system.
Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation.
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
Next-generation sequencing to generate interactome datasets.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Toward an understanding of the protein interaction network of the human liver.
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.
A proteome-scale map of the human interactome network.
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
Widespread macromolecular interaction perturbations in human genetic disorders.
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.
An inter-species protein-protein interaction network across vast evolutionary distance.
APR3 modulates oxidative stress and mitochondrial function in ARPE-19 cells.
Dimerization quality control ensures neuronal development and survival.
A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display.
FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
C4orf19 inhibits colorectal cancer cell proliferation by competitively binding to Keap1 with TRIM25 via the USP17/Elk-1/CDK6 axis.
Geniposide ameliorates dextran sulfate sodium-induced ulcerative colitis via KEAP1-Nrf2 signaling pathway.
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.
Multimodal cell maps as a foundation for structural and functional genomics.
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Deep research report on KEAP1