A Novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa.
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Overexpression of vreI induces a defined set of target genes.
"overexpression of vreI upregulates 30 genes"
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VreR is an anti-sigma regulator for VreI that is required for its function and inhibits it under non-inducing conditions.
"In conclusion, VreR is an anti-sigma regulator for VreI that is both required for the function of VreI and inhibits its activity under non-inducing conditions."
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VreI is membrane-associated only through VreR; otherwise it is in the cytosolic fraction.
"VreI is associated to the membrane through the VreR sigma factor regulator"
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PUMA3 regulates virulence in zebrafish embryos.
"we have demonstrated, using zebrafish (Danio rerio) embryos as an infection model, that PUMA3 is involved in the regulation of P. aeruginosa virulence"
Extracytoplasmic function sigma factors in Pseudomonas aeruginosa.
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Review grouping the P. aeruginosa ECF sigma factors by function.
"the iron starvation σ (PvdS, FpvI, HasI, FecI, FecI2 and others), the cell wall stress ECFσ AlgU, SigX and SbrI, and the unorthodox σVreI involved in the expression of virulence"
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
UniProt entry for vreI (PA0675)