GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

Source of IEA annotations for GO:0006812, GO:0008324, GO:0055085 based on IPR003445

GO_REF:0000043

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Source of GO:0006811 annotation from UniProt keyword KW-0406 (Ion transport)

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

Source of GO:0005886 (plasma membrane) annotation

GO_REF:0000108

Automatic assignment of GO terms using logical inference

Source of GO:0098655 inferred from GO:0008324 molecular function

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

Source of GO:0030001 (metal ion transport) - questionable mapping for K+ transporter

file:DESVH/Q72F05/Q72F05-deep-research-falcon.md

Deep research review of Q72F05 (DVU_0413) TrkH-family potassium uptake protein

DVU_0413 is annotated as TrkH-family K+ uptake membrane subunit containing TrkH (PF02386) and Cat_transpt (IPR003445) domains

"Target verification: The UniProt record provided maps Q72F05 to DVU_0413 from Desulfovibrio vulgaris Hildenborough and annotates it as a TrkH-family potassium uptake protein with TrkH (PF02386) and cation transporter/cation transpt (IPR003445) domains"
TrkH/KtrB-family pores are selective for K+ and operate as low-affinity, membrane-potential-driven channels

"TrkH/KtrB-family pores are selective for K+ and operate as low-affinity, membrane-potential-driven channels rather than primary active transporters; ATP acts as a ligand for the cytosolic RCK ring (not as a direct energy source for pumping)"
TrkH/KtrB homologs are integral inner-membrane proteins forming the K+ conductance pathway

"Cellular localization: TrkH/KtrB homologs are integral inner-membrane proteins forming the K+ conductance pathway; DVU_0413's TrkH domain architecture and transmembrane nature support inner-membrane localization"
Trk/Ktr systems exploit membrane potential for inward K+ flux when extracellular K+ is high

"Trk/Ktr systems are generally ATP-gated channels that exploit the membrane potential for inward K+ flux when extracellular K+ is relatively high (mM range)"
KtrAB-type complexes are gated by RCK octameric rings with ATP/ADP-dependent activation

"KtrAB-type complexes are gated by RCK octameric rings (KtrA/TrkA); ATP binding (vs ADP) adopts an activating conformation"
Trk-type K+ transporters are key features associated with salinity adaptation

"Trk-type K+ transporter ranked as the top genomic feature linked to high salinity, highlighting the ecological importance of TrkH-mediated salt-in strategies"