Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network.
The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells.
A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains.
A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis.
Downstream regulator TANK binds to the CD40 recognition site on TRAF3.
Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor.
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism.
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.
Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.
The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling.
The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.
WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation.
BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation.
Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection.
TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor.
The MYND domain-containing protein BRAM1 inhibits lymphotoxin beta receptor-mediated signaling through affecting receptor oligomerization.
A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas.
Identification and characterization of receptor-interacting protein 2 as a TNFR-associated factor 3 binding partner.
The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.
SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3.
A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.
Citrobacter rodentium NleB Protein Inhibits Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production.
DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS.
Architecture of the human interactome defines protein communities and disease networks.
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
TRAF3 can interact with GMEB1 and modulate its anti-apoptotic function.
TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1.
A novel RING finger protein interacts with the cytoplasmic domain of CD40.
A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40.
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
TRAF3 binds TICAM1:activated TLR4 complex
Auto-ubiquitination of TRAF3
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4
Defective TRAF3 does not transmit the signal
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer
K63polyUb-cIAP1,2 ubiquitinates TRAF3
Protesomal degradation of K48polyUb-TRAF3
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
TRAF3:NIK binds TRAF2:cIAP1/2
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40
TRAF2:cIAP1/2 complex binds FN14:TWEAK
OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
TICAM1-dependent activation of IRF3/IRF7
Auto-ubiquitination of TRAF3 within activated TLR3 complex
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA
TRAF3 binds to TRIF:activated TLR3 complex
TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
Recruitment of TRAF3 to MAVS
Phosphorylation and release of IRF3/IRF7
OTUD5 deubiquitinates TRAF3
Negative regulation of DDX58/IFIH1 signaling by RNF216
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
SARS-CoV-1 M protein interacts with TRAF3
TBK1 or IKBKE forms homodimers
TBK1, IKBKE are autophosphorylated at Ser172
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
TBK1 is phosphorylated within the activated TLR4 complex
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
OPTN binds TBK1 within the activated TLR4 complex
IKKε (IKBKE) is ubiquitinated within the activated TLR4
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex
TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3
IKKε (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3
TBK1 is phosphorylated within the activated TLR3 complex
OPTN binds TBK1 within the activated TLR3 complex
IKKε (IKBKE) is phosphorylated within the activated TLR3 complex
IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response.
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6.
Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
DUBA: a deubiquitinase that regulates type I interferon production.
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex.
Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response.
TRAF3 curation notes: literature synthesis and per-annotation rationale