Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The sonic hedgehog-patched-gli pathway in human development and disease.
The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane.
Patched1 interacts with cyclin B1 to regulate cell cycle progression.
Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes.
Inhibition of GLI1 gene activation by Patched1.
Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development.
Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development.
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors.
The hedgehog receptor patched is involved in cholesterol transport.
Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity.
Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Structural basis of sterol recognition by human hedgehog receptor PTCH1.
The energetics and ion coupling of cholesterol transport through Patched1.
Inhibiting hedgehog signal by a patched-1 antibody.
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.
Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident.
Characterization of two patched receptors for the vertebrate hedgehog protein family.
Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling
Hh-Npp binds GAS1 and PTCH
Hh-Npp binds CDON and PTCH
SMURF1/2 dissociates from ub-PTCH1