Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Electronic Gene Ontology annotations created by ARBA machine learning models

Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.

FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts.

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells.

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells.

Membrane expression of DR4, DR5 and caspase-8 levels, but not Mcl-1, determine sensitivity of human myeloma cells to Apo2L/TRAIL.

Identification of an antiapoptotic protein complex at death receptors.

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling.

Expression of the Bcl-2 protein BAD promotes prostate cancer growth.

Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis.

Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity.

Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway.

Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis.

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD.

Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells.

Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP.

The endoplasmic reticulum stress response in aging and age-related diseases.

N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism.

Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes.

PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression.

A reference map of the human binary protein interactome.

A physical wiring diagram for the human immune system.

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

Characterization of two receptors for TRAIL.

Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.

Caspase-8 processing in the DISC

Trimerization of TRAIL:TRAIL receptor complex

TRAIL-mediated dimerization of procaspase-8

TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10

FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling

FLIP(S) and procaspase-8 form heterodimer

Caspase-8 and FLIP(L) processing at DISC

TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes

TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2

FLIP(L) and procaspase-8 form heterodimer

TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8

TRAIL:TRAIL receptor trimers bind FADD

TRAIL binds TRAIL receptors