Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor.
Preparation of the anti-HLJ1 monoclonal antibodies and establishment of method for detection of the antigen.
The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.
A novel neuron-enriched protein SDIM1 is down regulated in Alzheimer's brains and attenuates cell death induced by DNAJB4 over-expression in neuro-progenitor cells.
Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Loss of function variants in DNAJB4 cause a myopathy with early respiratory failure.
-
Biallelic loss-of-function DNAJB4 variants cause an autosomal recessive myopathy with early respiratory failure (CMYO21).
-
DNAJB4 normally localizes to the Z-disc and is absent from patient muscle and fibroblasts; knockout muscle accumulates Z-disc proteins and chaperones, indicating a role in myofibril/Z-disc proteostasis.
Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver.