Fetched with just fetch-gene PSEAE Q9HUJ0 --alias PA4975; accession matches the
worklist. Unreviewed TrEMBL entry, no gene symbol. No deep-research provider was
used. NCBI E-utilities and Europe PMC search were unavailable; papers mentioning
PA4975 were found by searching the local publication cache. PMID:25085734 is
abstract-only (no PMC copy).
| PTN node | node term | n_seeds | leaf IBAs | seed annotation (term, evidence, PMID) | verdict | rationale | other seeds | IBD stands without this seed? |
|---|---|---|---|---|---|---|---|---|
| PTN000024521 | GO:0003955 NAD(P)H dehydrogenase (quinone) activity | 4 | 71 (30 taxa) | GO:0003955, IMP, PMID:25085734 (PseudoCAP) | SOUND | The abstract reports in vitro quinone reduction by the purified P. aeruginosa orthologs, and Ryan et al. name PA4975 among them. The term is right; the evidence code should be IDA (PSEUDOCAP WRONG_EVIDENCE_CODE, PROBABLE), as recorded for PA1204 from the same paper. | Human NQO1 (P15559; EXP/IDA GO:0008753 and GO:0050136, PMID:9271353, PMID:8999809), mouse Nqo1 (MGI:103187), rat Nqo1 (RGD:2503) | Yes; NQO1 is the reference enzyme for this activity |
One PSEUDOCAP defect (WRONG_EVIDENCE_CODE, PROBABLE); no GO_CENTRAL defect. Node
caveat, not filed: the same node carries a cytosol IBD seeded by human NQO2
(P16083), so NQO2 orthologs, which prefer dihydronicotinamide riboside over
NAD(P)H, sit below the NAD(P)H quinone dehydrogenase IBD. The term still holds for
the clade as a quinone reductase, and PA4975 itself has the measured activity.