Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

Gene Ontology annotation based on curation of immunofluorescence data

Automatic assignment of GO terms using logical inference

Combined Automated Annotation using Multiple IEA Methods

cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III.

Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium

The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.

Drosophila ribosomal protein PO contains apurinic/apyrimidinic endonuclease activity.

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

Identification of redox/repair protein Ref-1 as a potent activator of p53

Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.

Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals.

Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product

Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.

Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.

Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch.

Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism.

Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases.

Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter.

An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA.

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

Characterization of human ribosomal protein S3 binding to 7,8-dihydro-8-oxoguanine and abasic sites by surface plasmon resonance.

Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1.

Characterization of a wide range base-damage-endonuclease activity of mammalian rpS3.

Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).

UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles.

Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.

Human ribosomal protein S3 (hRpS3) interacts with uracil-DNA glycosylase (hUNG) and stimulates its glycosylase activity.

APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA.

HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy.

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.

SIRT1 deacetylates APE1 and regulates cellular base excision repair

Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1.

Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen.

A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus.

Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1.

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

APE1 incision activity at abasic sites in tandem repeat sequences

R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation.

Nuclear complex of glyceraldehyde-3-phosphate dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I protect smooth muscle cells against oxidant-induced cell death.

Architecture of the human interactome defines protein communities and disease networks.

A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Resolution of Abasic Sites (AP sites)

Displacement of UNG glycosylase by APEX1 at the AP site

Displacement of TDG glycosylase by APEX1 at the AP site

Displacement of SMUG1 glycosylase by APEX1 at the AP site

Displacement of NTHL1 glycosylase by APEX1 at the AP site

Displacement of MBD4 glycosylase by APEX1 at the AP site

Displacement of OGG1 glycosylase by APEX1 at the AP site

Displacement of MUTYH glycosylase by APEX1 at the AP site

Displacement of MPG glycosylase by APEX1 at the AP site

APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site

Recruitment of POLB to the AP site

FEN1 bound to PCNA and APEX1 cleaves flap ssDNA

PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1

POLD,POLE-mediated DNA strand displacement synthesis

LIG1 binds APEX1 and PCNA at SSB

Excision of the abasic sugar phosphate (5'dRP) residue

POLB incorporates the first 3' dNMP and displaces 5'ddRP

Recruitment of POLB to oxidatively damaged AP site

Oxidative damage to the AP site

PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1

LIG1 bound to APEX1 and PCNA ligates SSB

LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA

Deep research report on APEX1