daf-15 review notes

• Fetched UniProt id confirmed: G5EEV7 (WormBase WBGene00000911, GeneID 177770). 5 GOA rows.
• Deep research API unavailable; literature compiled manually in daf-15-deep-research-manual.md.

Evidence notes

• DAF-15 = Raptor ortholog PMID:15253933
• TORC1 membership in worm PMID:18804378
• Functional TORC1 activation through DAF-15 fusion [PMID:23705068 "We fused a 22-amino acid fragment of the C-terminal end of rap-1 to the C-terminal end of daf-15 and named it daf-15::rap-1(22)."; "This indicates that hyperactivation of TORC1 was sufficient to support L1 growth in mmBCFA-depleted animals."]
• Lifespan IGI: let-363+daf-15 RNAi from L4 extends lifespan, pha-4 dependent PMID:18804378.
• Dauer IMP: daf-15(m81) dauer-like larvae [PMID:3350212, abstract only].

Decisions

• TOR signaling IEA -> MODIFY to TORC1 signaling (GO:0038202): Raptor is TORC1-specific.
• TORC1 complex (IEA, ISS) -> ACCEPT (core location/complex).
• Lifespan, dauer -> KEEP_AS_NON_CORE (organismal outputs of TORC1 signaling).
• NEW MF protein-macromolecule adaptor activity (GO:0030674), ISS to human RPTOR, consistent with
  the DROME/raptor review; no worm biochemistry exists, flagged as a question.
• No NEW process terms (growth/fat/germline phenotypes are downstream of TORC1 signaling and fail the NEW bar).