Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A Toll-like receptor recognizes bacterial DNA.
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.
TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs.
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.
Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.
Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells.
Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9.
Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae.
FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation.
TLR9 and RIG-I signaling in human endocervical epithelial cells modulates inflammatory responses of macrophages and dendritic cells in vitro.
Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2.
Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice.
PI3K-containing complexes phosphorylate PIP2 to PIP3
Full-length TLR3/7/8/9 binds to UNC93B1
TLR folding by chaperones GP96 and CNPY3
UNC93B1 delivers endosomal full-length TLRs to endolysosome
Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex
TLR9 processing at neutral pH
Endosomal TLRs pass through the Golgi
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer
Engulfed CpG DNA binds to endosomal full-length TLR9
Engulfed CpG DNA binds to endosomal C-ter TLR9
Rab5-mediated recruitment of class III PI3K to TLR9
C-ter TLR9 dimer binds HCQ
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
MyD88 interacts with the activated TLR receptor 7, 8 or 9
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells.
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9.
Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.
Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.
Falcon deep research report on TLR9