Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
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CKMT2 was identified among phosphoproteins of mitochondria isolated from human skeletal muscle, confirming its native mitochondrial localization.
"functional mitochondria isolated from resting human muscle"
Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes.
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CKMT2 (sarcomeric MtCK) and CKMT1 (ubiquitous MtCK) are encoded by separate nuclear genes; the sarcomeric isoenzyme is heart/skeletal-muscle specific and contains a transit peptide for mitochondrial import.
"separate nuclear genes encode two closely related, tissue-specific isoenzymes of MtCK"
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
creatine + ATP => phosphocreatine + ADP [CK octamer]
Creatine kinase S-type, mitochondrial (human)
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CKMT2 is a peripheral mitochondrial inner-membrane protein on the intermembrane side that exists as an octamer of four homodimers and binds cardiolipin; it reversibly catalyzes creatine + ATP = N-phosphocreatine + ADP.
"Mitochondrion inner membrane; Peripheral membrane"