Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Developmental and cell biological functions of the Drosophila DEAD-box protein abstrakt.
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
Defining the membrane proteome of NK cells.
Dynamic protein-protein interaction wiring of the human spliceosome.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA.
A proteome-scale map of the human interactome network.
Bruton's tyrosine kinase phosphorylates DDX41 and activates its binding of dsDNA and STING to initiate type 1 interferon response.
Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.
Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
Architecture of the human interactome defines protein communities and disease networks.
A reference map of the human binary protein interactome.
Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
DDX41 is required for cGAS-STING activation against DNA virus infection.
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Recombinant DDX41 unwinds tested DNA duplexes with ATP, does not unwind the tested tailed RNA duplexes, and also promotes ATP-independent DNA strand annealing. Human macrophage fractionation supports stimulus-dependent cytosolic accumulation.
DDX41 ubiquitination by TRIM21
DDX41 binds bacterial c-di-AMP, c-di-GMP
Formation of the Spliceosomal C* complex
Formation of the Spliceosomal P complex and exon ligation
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells.
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.
DDX41 regulates the expression and alternative splicing of genes involved in tumorigenesis and immune response.
Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia.
DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells.
Ribosome profiling analysis reveals the roles of DDX41 in translational regulation.
DDX41 source and assay guide