Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase.
-
Reconstituted human CYP4V2 directly hydroxylates terminal carbons of C12, C14 and C16 fatty acids; C8 activity was not detected in the inspected assay.
"Octanoic acid was not detectably ω-hydroxylated by CYP4V2"
CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant.
-
Human CYP4V2 is detected in ocular epithelia and colocalizes with an ER marker in ARPE-19 cells. Purified enzyme produces terminal and smaller penultimate hydroxy products from EPA and DHA.
"19-hydroxy-EPA, 20-hydroxy-EPA, 21-hydroxy-DHA, and 22-hydroxy-DHA"
Architecture of the human interactome defines protein communities and disease networks.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The canonical retinoid cycle in rods (twilight vision)
CYP4V2 omega-hydroxylates DHA to HDoHE
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Official CYP4V2 UniProt record and alternative products
CYP4V2 source evidence and interpretation guide