dpm2 (S. pombe, SPBC21B10.11, UniProt Q9USW6) notes

Identity

• UniProt Q9USW6 (DPM2_SCHPO), 72 aa, multi-pass ER membrane protein, DPM2 family (PANTHER PTHR15039) [UniProt:Q9USW6].

Function

• No S. pombe-specific experiments found. Function is inferred from the human ortholog: [UniProt:Q9USW6 "Regulates the biosynthesis of dolichol phosphate-mannose."]
• Human DPM2 enhances DPM synthase activity and stabilises DPM3 [PMID:10835346 "DPM synthase activity was 10 times higher in the presence of DPM2, indicating that DPM2 also plays a role in the enzymatic reaction."; "Therefore, DPM2 stabilizes DPM3 and DPM3 stabilizes DPM1."].
• S. pombe has a DPM2-like protein PMID:10835346; only dpm3 was tested in that study.

Location

• ER in the ORFeome YFP screen PMID:16823372; UniProt ER membrane (by similarity).

Comparison

• No S. cerevisiae ortholog (budding yeast Dpm1 is single-subunit; no DPM2/DPM3). Consistent with the human DPM2 review (core MF GO:0008047).

GO-CAM

• gomodel:671ae02600003596 activity 671ae02600003604: dpm2 enables GO:0008047 (ISO to human O94777), positively regulates dpm1 activity, ER membrane, part_of GO:0180047. Agrees.