Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.
Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation.
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification.
Centriolar distal appendages activate the centrosome-PIDDosome-p53 signalling axis via ANKRD26.
ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis.
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Human ANKRD26 overexpression inhibits ligand-triggered receptor internalization in murine Ba/F3 cells; human hematopoietic models separately support altered cytokine signaling.
"In contrast, the presence of human ANKRD26 almost completely abrogated MPL internalization, even after 60 min of TPO exposure"
Ankrd26 is a retinoic acid-responsive plasma membrane-binding and -shaping protein critical for proper cell differentiation.
A hierarchical pathway for assembly of the distal appendages that organize primary cilia.
ANKRD26 original-paper evidence and ontology notes