PDX1 (P16451, YGR193C) notes

Module: pyruvate_metabolism, role = PDHX / E3-binding protein (structural adaptor). Not in any YeastCyc reaction (missing from PYRUVDEHYD-PWY gene list).

Evidence journal

• Structural role PMID:2007123
• pdx1 complex lacks E3 PMID:2007123
• Lipoyl domain dispensable PMID:2007123
• Stoichiometry PMID:7947791
• Matrix, lipoyl + PSBD domains only [UniProt:P16451]

Decisions

• acyltransferase activity IEA REMOVE (no catalytic domain; non-catalytic subunit). acetyltransferase complex MODIFY to PDH complex.
• Structural molecule activity (IBA/IDA/IMP) ACCEPT; NEW GO:0030674 adaptor (as for human PDHX and the module).