Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

UniProt:A6QL63

UniProt record for human ABTB3 (A6QL63)

UniProt describes human ABTB3 as an ankyrin repeat- and BTB/POZ domain-containing protein with inferred synaptic function and single-pass membrane association.

PMID:37261953

Btbd11 supports cell-type-specific synaptic function

Mouse Btbd11 is a conserved inhibitory-interneuron synaptic protein that binds PSD-95, localizes to glutamatergic synapses, stabilizes PSD-95, and supports glutamatergic synaptic signaling.

file:human/ABTB3/ABTB3-deep-research-manual.md

Manual fallback research summary for ABTB3

Falcon deep research timed out and the configured perplexity-lite fallback failed for quota reasons; this manual file records the evidence synthesis used for the review.

file:projects/PROTEOSTASIS/reports/pn_projection/pn_projected_new_to_goa.tsv

Proteostasis PN projected new-to-GOA annotations

PN projects ABTB3 to GO:1990756 from the Cul3 substrate receptor group, but the projection report marks these cases for manual gene-level review before changing gene annotations.