Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors.
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The original cloning study identified human GLIPR1 and reported high expression in glioblastoma.
"We report the cloning of a cDNA encoding GliPR (glioma pathogenesis-related protein), a protein that is structurally similar to plant pathogenesis-related proteins."
RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin.
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An independent cloning study reported broad adult-tissue expression and enrichment in glial-derived tumor lines.
"Northern hybridization analysis revealed that in fetal tissue RTVP-1 RNA was detected only in the kidney, but its expression was ubiquitous in adult tissues including brain."
Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells.
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RTVP-1b is an alternative human isoform that diverges after residue 141.
"The deduced protein was 237 amino acids in length, sharing the N-terminal 141 amino acids with RTVP-1."
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RTVP-1b overexpression promotes glioma-cell proliferation but not migration.
"Overexpression of RTVP-1b increased glioma cell proliferation but did not affect cell migration."
Structural studies of human glioma pathogenesis-related protein 1.
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Human GLIPR1 contains a signal peptide, CAP domain, and transmembrane domain.
"GLIPR1 is composed of a signal peptide that directs its secretion, a conserved cysteine-rich CAP (cysteine-rich secretory proteins, antigen 5 and pathogenesis-related 1 proteins) domain and a transmembrane domain."
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The isolated human CAP domain coordinates zinc in its central cavity.
"the putative binding cavity coordinates Zn2+ similarly to snake-venom CRISPs"
RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer.
Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling.
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GLIPR1 overexpression induces apoptosis and suppresses colony growth in human cancer cells.
"Overexpression of GLIPR1 in cancer cells leads to suppression of colony growth and induction of apoptosis."
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GLIPR1-driven apoptosis proceeds through ROS and JNK signaling.
"GLIPR1 up-regulation increases the production of reactive oxygen species (ROS) leading to apoptosis through activation of the c-Jun-NH(2) kinase (JNK) signaling cascade."
GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction.
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Restored GLIPR1 reduces c-MYC and cell-cycle progression in prostate cancer cells.
"Restoration of GLIPR1 expression in prostate cancer cells downregulated c-myc levels, inhibiting cell-cycle progression."
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GLIPR1 promotes c-Myc ubiquitination and degradation.
"GLIPR1 also promoted c-Myc protein ubiquitination and degradation by glycogen synthase kinase-3alpha- and/or CK1alpha-mediated c-Myc phosphorylation."
Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2.
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GLIPR1 interacts with Hsc70 in a pathway that destabilizes SP1/c-Myb and suppresses AURKA/TPX2.
"GLIPR1 interacts with heat shock cognate protein 70 (Hsc70); this interaction is associated with SP1 and c-Myb destabilization and suppression of SP1- and c-Myb-mediated AURKA and TPX2 transcription."
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Recombinant GLIPR1 ectodomain induces apoptosis and mitotic catastrophe.
"Recombinant GLIPR1-DeltaTM protein inhibited AURKA and TPX2 expression, induced apoptosis and MC, and suppressed orthotopic xenograft tumor growth."
RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK.
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GLIPR1 promotes glioma-cell spreading, migration, and invasion in an N-WASP-dependent manner.
"We found that RTVP-1 increased cell spreading, migration and invasion and these effects were at least partly mediated by N-WASP."
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GLIPR1 decreases the inhibitory N-WASP-hnRNPK association.
"overexpression of RTVP-1 decreased the association of N-WASP and hnRNPK."
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Reciprocal co-immunoprecipitation and FRET support direct GLIPR1-N-WASP interaction.
"RTVP-1 and N-WASP showed FRET efficiency of 33.43 + 2.72%, suggesting a direct interaction of these two proteins in glioma cells."
Defining the membrane proteome of NK cells.
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The study defined the membrane proteome of the YTS NK-like cell line.
"The present study was initiated to define the composition of the membrane proteome of the Natural Killer (NK) like cell line YTS."
Architecture of the human interactome defines protein communities and disease networks.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Expression of GLIPR1
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Reactome models GLIPR1 transcription, translation, and plasma-membrane placement.
"The GLIPR1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein."
Exocytosis of azurophil granule membrane proteins
Local PAINT export for PTHR10334
GO-CAM source model for regulation of oolemmal binding multimeric complex formation
UniProt entry for human GLIPR1 (P48060)
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Canonical human GLIPR1 is a single-pass membrane CAP-family protein.
"Single-pass membrane protein"
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UniProt records ALOXE3 and HTT interactions.
"P48060; Q9BYJ1: ALOXE3"
Manual literature synthesis for GLIPR1